| Objective:explore effectiveness and safety of Sertraline for adjuvant therapy associated with depressive teenagers of bronchial asthma. Detect thymoleptics sertraline for serum IL-4 levels of teenagers bronchial asthma. Methods:bronchial asthma cases adolescent patients were randomly divided into two groups:treatment group in 40 cases, based on the conventional treatment with thymoleptics sertraline, 50mg/d, no improvement of symptoms of 4 weeks to 100mg/d, for 12 weeks. Add placebo group qd. According to the specific circumstances to 2/d, treatment for 12 weeks, two groups did not use any other thymoleptics.37 cases, given placebo for 12 weeks. At the end of the 6th,12th thymoleptics and asthma curative effect, safety evaluation and measured serum IL-4 concentration (with muon mo/l). Statistical analysis software for statistical method for counting SPSS13.0, using X-ray inspection data, measurement data2 by independent sample t-test, P＜0.05.Results:the treatment group and control group before separately Hamilton depression rating scale (Hamilton depression rating for depression, HRSD) (24), the treatment group for 28.3±3.4, control group for 27.7±3.7, two groups of difference was statistically significant (P= 0.51), six weeks after treatment group and control group Hamilton depression rating scale respectively in treatment group and control group for 17.3±3.3, for 23.5±3.9, two groups of comparisons difference was statistically significant (P＜0.05).12 weeks treatment Hamilton depression rating scale, the treatment group and control group for 10.1±2.3 17.5±3.1, two groups of comparisons difference was statistically significant (P＜0.05). Treatment of asthma, the treatment group sixth weekend for 50% of total effective treatment of asthma, and the total effective rate of treatment group 32.4%, two group total effectiveness was statistically significant (P＜0.05). Treatment of asthma, the treatment group twelfth weekend for the treatment of the total effective rate in treatment of asthma and the total effective rate of endoscopic mucosectomy, two group total effectiveness is significant difference was statistically significant (P＜0.05). Sixth, the treatment group therapy at the weekend to the percentage of value for both FEV1 (FEV1%) and the percentage of expected value PEF) (PEF 79.3±10.7 77.4±for group, FEV1 9.3 percent,70.1±8.4 percent for PEF 69.4±9.15, two groups of comparisons difference was statistically significant (P＜0.05). This weekend, the treatment group therapy 12 %, PEF FEV1 95.1±2.1 percent for 93.3±4.7 percent, and control for FEV1 PEF 81.5%±7.3 8.03±6.9, two groups of comparisons difference was statistically significant (P＜0.05). Sixth, the treatment group weekend treatment level of serum IL -4 47.16±10.1 appear in serum, IL-4 levels for 49.69±10.32, two groups of comparisons difference was statistically significant (P＜0.05). This weekend, the treatment group therapy 12th level of serum IL-4 for 43.13±10.15, in serum IL-4 levels for 47.99±10.34, two groups of comparisons difference was statistically significant (P＜0.05). Two treatment groups 6,12 Asberg weekend's antidepressant effects evaluation (SERS) rating scale for comparison, the treatment group and control group 3.13±0.22 treatment for 3.20±0.25, two groups of comparisons difference was statistically significant (P＞0.05). This weekend, the treatment group therapy 12th SERS score for 5.10+0.31, control (SERS 4.93 score for the two groups, the difference was not statistically significant (P＞0.05).Conclusion First, thymoleptics sertraline for depressive symptoms of adolescent patients with bronchial asthma is effective and safety.Second, associated with depressive teenagers bronchial asthma taking thymoleptics, serum IL-4 levels decreased obviously, whether patients are other inflammatory factor, but need further study.
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