Expressions Of ER,PR,Cerb-B2,P53,LRP,GST-π,TopoⅡ In Mucinous Carcinoma Of The Breast

Objective:Observe the expressions of ER,PR,Cerb-B2,lung resistanceprotein(LRP), glutathione-S-transferase(GST-π),topoisomeraseⅡ(TopoⅡ),tumor suppressor gene product P53 protein in breast mucinous carcinoma and its clinical significance.Methods:Immunohistochemistry(LDP) method was used to detect the expressions of ER,PR,Cerb-B2,P53,LRP,GST-π,TopoⅡin 42 cases of mucinous carcinoma of the breast,Statistical analyses were used to study the relationship between the test results and different clinicopathological parameters.Results:42 cases of mucinous breast cancer,there are 10 cases of lymph node metastasis in patients with mixed mucinous carcinoma of 7 cases,3 cases of pure mucinous carcinoma,The axillary's metastasis node numbers was related to the different histological types,p=0.027,r=0.367;The expressions of ER,PR,Cerb-B2,P53,LRP,GST-π,TopoⅡin this group were 80.9%,85.7%,47.6%,45.2%,85.7%, 64.3%,52.4%respectively;the ER was distinctly related to the different histological types and the expressions of P53,(p＜0.05);the expressions of P53 was related to the expressions of GST-π(p=0.003.r=0.478);LRP was related to GST-π(p=0.008.r=0.406);No relationship was found between P53 and LRP,TopoⅡ; The expressions of TopoⅡwas related the tumor diameter(p=0.03).And no relationship was found between ER,PR,Cerb-B2,TopoⅡ,LRP,GST-π,P53 protein in mucinous carcinoma of the breast and patient's age,menstrual status,axillary lymph node metastasis.Conclusion:Combined detection of TopoⅡ,LRP,GST-π,P53 protein in mucinous breast carcinoma and analysis of hormone receptor status and clinicopathological factors can help assess the biological behavior of the mucinous breast carcinoma and have important reference value to the chemotherapy and endocrine therapy.