The Effects Of Prenatal Exposure To 1800MHz Electromagnetic Waves On Apoptosis And NGF In The Hippocampus In Offspring Rats

Objective To study the effects of Prenatal exposure to 1 800 MHz electromagnetic waves on apoptosis and nerve growth factor in hippocampus in offspring rats.Methods 48 SD rats at age of 7 week-old were randomly divided into four groups (8 rats in each) after one week for environmental adaptation and successful mating. Rats in the exposure groups were respectively and continuously radiated between 0 days and 20 days of pregnancy (12 hours/day) by 1800MHz electromagnetic waves with power density of 0.5 mW/cm2 or 1.0 mW/cm2. Simultaneously, two sham-controls were carried out respectively. The pregnant rats and control group were generally and continuously radiated by 1800 MHz microwave radiation with power density of 0.5 mW/cm2 and 1.0 mW/cm2 respectively. The effects on apoptosis and NGF in hippocampus were observed and detected by method of the TUNEL and the ELISA, when offspring rats are 3 and 7 weeks old.Results Power density of 0.5 mW/cm2 increase apoptosis on hippocampus in offspring rats both in the 3rd and 7th week; Power density of 1.0 mW/cm2 increase apoptosis in the hippocampus in offspring rats in the 7th week, and increase NGF on hippocampus in offspring rats both in the 3rd and the 7th week.Conclusion Prenatal exposure to 1 800 MHz electromagnetic waves increase the apoptosis and NGF in the hippocampus in offspring rats.