Study The Relationship Between ACAT2 Gene Polymorphism With Essential Hypertension And Blood Lipids In Gansu Han And Yugu Population

Objective: To investigate if the acyl-coenzyme A: cholesterol acyltransferase2 (ACAT2) gene polymorphism is associated with essential hypertension in Gansu Han and Yugu population, and the relationship of the polymorphism with blood lipids and blood glucose.Methods: Polymerase chain reaction restriction fragment length polymorphisms (PCR-RELP) technique was used to analyze the 734C/T polymorphism. The blood lipids and blood glucose were also measured. The study covered 108 hypertensives and 121 controls of Han minority and 102 hypertensives and 112 controls of Yugu minority.Results:(1) The levels of the blood lipids in hypertensives were higher than those in controls of Han and Yugu minority (P<0.05).(2) The frequencies of ACAT2, CC, CT, TT genotypes in Han hypertensive and that in control were 65.7%, 29.6%, 4.6% and 52.9%, 38.0%, 9.1%, respectively. There was no significant difference in genotypes between hypertensives and controls (χ~2 =4.402, P=0.111). The T allele of ACAT2 was significantly lower in hypertensives in Han population (χ~2=4.685, P=0.030). The frequencies of CC, CT, TT genotypes in Yugu hypertensive and that in control were 64.7%, 33.3%, 2.0% and 51.8%, 42.9%, 5.4%. There was also no significant difference in genotypes (χ~2=4.544, P=0.103). In Yugu population, the T allele was significantly lower in hypertensives (χ~2=4.025, P=0.045).(3) The level of blood lipids and blood glucose of ACAT2 genotype in hypertensives and controls was no significant difference in Hun and Yugu minority (P>0.05).Conclusion:(1) The hypertensives have hyperlipidemia in Han and Yugu population.(2) The T allele may be protective against essential hypertension in Han and Yugu population.(3) The ACAT2 gene 734C/T polymorphism was not affect the level of fasting blood lipid and blood glucose in hypertensives of Han and Yugu population.