Expression Of ERCC1 And MRP In The Patients In Gastric Cancer

Objective: Explore the nucleotide excision repair gene ERCC1 (excision repair cross - complementing 1) and multidrug resistance-associated protein (multidrug resistance-associated protein, MRP) expression in gastric cancer-related clinical factors.Methods: Using RT-PCR (reverse transcription - polymerase chain reaction) were detected 64 cases of gastric cancer tissues and adjacent tissues in ERCCL gene and MRP gene mRNA expression detected by immunohistochemistry and MRP gene ERCC1 protein expression, analysis of ERCC1, MRP gene and protein expression and gastric cancer.Results: 1.46.88% (30/64) of gastric cancer tissues, 10.94% (7 / 64) of gastric cancer tissue exist Low ERCC1 gene expression, and its expression in gastric cancer tissues and between tissues have significant differences, (P=0.001) .2.ERCC1 expression and the degree of differentiation of gastric cancer significantly correlated (P = 0.003 <0.05), while patients with gastric cancer by sex, age and the relationship between pathological stage of the tumor was no significant correlation.3.39.06% (25/64) of gastric cancer tissues, 17.18% (11/64) of gastric cancer tissues that exist in ERCC1 protein expression (-), its expression in gastric cancer tissues and between tissues has significant difference (P = 0.006).4.68.75% (44/64) of gastric cancer tissues, 26.56% (17/64) of gastric cancer tissues that exist in high expression of MRP gene expression in gastric cancer tissue and between adjacent tissues have significant differences (P <0.05).5.MRP gene expression and the degree of differentiation of gastric cancer significantly correlated (P = 0.044 <0.05), while patients with gastric cancer by sex, age and the relationship between pathological stage of the tumor was no significant correlation.6.81.25% (52/64) of gastric cancer tissues, 39.06% (25/64) of gastric cancer tissue MRP proteins exist Tatsu (+), and its expression in gastric cancer tissues and between tissues have significant differences (P <0.05 ).7. There is no correlation bettwen ERCC1 gene expression and MRP gene expression in gastric cancerConclusion: Low expression of ERCC1 or high expression of MRP in gastric cancer has played an important role, not only can be used as the detection of early diagnosis of gastric cancer indicators, but also has prompted a certain role for gastric cancer to determine the degree of differentiation. And there is no correlation bettwen ERCC1 gene expression and MRP gene expression in gastric cancer.