A Study For The Expression Of CD44v6,Smad7 In Endometriosis

Objective: To investigate the expression and the relativity of CD44v6 and Smad7 in endometriosis for exploring the role of CD44v6 and Smad7 in the pathogenesis of endometriosis.Methods: Immunohistochemistry was used to detect the expression of CD44v6 and Smad7 in the ectopic endometrium of 30 cases (ectopic endometrium group) , in the eutopic endometrium of 25 cases (eutopic endometrium group) with endometriosis and in the normal endometrium of 30 cases without endometriosis (control group).Results: The CD44v6 in ectopic endometrium group with strong positive expression mainly , in the eutopic endometrium group and the control group with main negative and weakly positive expression . The CD44v6 immunoreactivity of ectopic endometrium group was higher than that of eutopic endometrium group and the control group , the differences were statistically significant (P=0.001<0.05, P=0.001<0.05 ); increased expression of CD44v6 immunoreactivity was detected in control group compared with eutopic endometrium group , the difference was ststistically significant (P=0.028 <0.05 ) ; we also found CD44v6 in eutopic endometrium group and the control group of the secretory phase endometrium tissues , respectively , higher than the proliferative phase with the group , the differences were statistically significant (P=0.035<0.05, P=0.01<0.05).The Smad7 in ectopic endometrium group and eutopic endometrium group with negative and weakly positive expression mainly , in the control group with strong positive expression. The Smad7 immunoreactivity of ectopic endometrium and eutopic endometrium group were lower than that of the control group , the differences were statistically significant (P=0.046<0.05 , P=0.044<0.05) ; the Smad7 immunoreactivity of ectopic endometrium compared with the eutopic group, the difference was not statistically significant (P=0.899 >0.05) ; the expression of the Smad7 in the proliferative phase endometrium compared with secretory of eutopic endometrium group and control group, the differences were not statistically significant (P=0.521 >0.05, P=0.499>0.05) .The expression of CD44v6 had no corralation with that of Smad7 in each group endometrium (P>0.05).Conclusion:1. The up regulation of CD44v6 and the low regulation of Smad7 in endometriosis suggest that CD44v6 and Smad7 may play a role in the pathogenesis of endometriosis.2. The expression of CD44v6 had no corralation with that of Smad7 in each group endometrium , suggest that the pathogenesis of endometriosis may be regulated by them in different ways.