Investigation And Analysis Of Incidence Of Malignant Oral-maxillofacial Tumors In Hunan Area

ObjectivesWe aimed to investigate the incidence of malignant oral-maxillocfacial tumor'patients from 1989 to 2008 ,and to compare the inci-dence and proportion between 1989-1998 and 1999-2008,also to reflect initially the relationship between smoking,alcoholic consumption,betel quid chewing and the oral mucosa diseases of OSF,OLP,OLK with the incidence of oral mucosa squamous cell carcinoma.MethodsWe took a retrospective analysis on clinical data of malignant oral-maxillocfacial tumors by pathological diagnosis of 12 class 3-A hospitals from 1989 to 2008 in Hunan area,and followed up the oral mucosa squamous cell carcinoma patients during 2004-2008 years by telephone,whose clinical records about the information of smoking,alcoholic consumption and betel quid chewing are not detailed,to obtain the detail information of smoking,alcoholic consumption and betel quid chewing and analyze them.Results1. The incidence of malignant oral-maxillocfacial tumors from 1989 to 2008There are 5443 cases from 1989 to 2008,including 2158 cases from 1989 to 1998 and 3285 cases from 1999 to 2008. The average age of patients with malignant oral-maxillocfacial tumor from 1989 to 1998 is 53.0,and the ratio of male to female is 2.43:1;The average age of patients with malignant oral-maxillocfacial tumor from 1999 to 2008 is 52.5,and the ratio of male to female is 2.10:1. The predilection age stage is 41-70 years old,and we can find younger tendency during the two stages.Among malignant oral-maxillocfacial tumors,the predilection sites are tongue,parotid gland and gum by turns. Among oral-maxillocfacial squamous cell carcinoma,the predilection sites are tongue,gum and jaw bones by turns from 1989 to 1998,but cheek takes place of jaw bones from 1999 to 2008 cAmong malignant oral-maxillocfacial tumors,the epithelial tumors account majority,which making up 94.9% from 1989 to 1998 and making up 93.8% from 1999 to 2008. Among the epithelial tumors,squamous cell carcinoma account majority(64.2%,63.4%).Among salivary gland malignant tumors,the predilection sites are parotid gland ,Submandibular gland and palate gland by turns ,and mucoepidermoid carcinoma account first while the proportion of adenoeareinoma changes largely during the two stages.There are little seen malignant tumors coming from mesenchymal tissue in the oral-maxillocfacial region ,and the percentage is 2.8%. They mostly take place in jaw bones ,which making up 47.6% from 1989 to 1998 and making up 51.1% from 1999 to 2008. As to pathology type ,the most common are osteosarcoma, fribrosarcoma ,and malignant fibrohistiocytoma successively .2.The information of oral mucosa squamous cell carcinoma patients about smoking,alcoholic consumption,betel quid chewing and the oral mucosa diseases of OSF,OLP,OLK from 2004 to 2008The cigarettes smoked per day during 1 to 20 cigarettes account majority(70.5%),and the duration of smoking more than 20 years account 68.5%. The Brinkman index more than 400 account 73.1%, and the proportion of all sites except cheek and mouth floor has no change.The amount of alcohol intake less than and also containing 5 liang account 54.7%;The duration of drinking more than 20 years account 62.1%;The proportion of mouth floor increases a little(p<0.05).The proportion of cheek and tongue who chews betel quid increases obviously(p<0.05),and they make up 86.2% while tongue(64.8%) is major site . The proportion during 31 to 50 years old increases obviously(p<0.05),and the average age is 48.6,while the average age of patients who don't chew betel quid is 56.0.The predilection age of patients who are habitual cigarette smokers, alcohol consumers, and betel quid chewers is 40-60 years;The major sites are tongue(57.1%) and cheek(26.3%).There are 81 patients who are also diagnosed as OSF,and the average age is 47.3;the major site is tongue(58.0%) and cheek(33.3%). Patients who are also diagnosed as OLP or OLK,the major site is tongue . Conclusions1 .The predilection age stage of malignant oral-maxillocfacial tumors in Hunan area is 41-70 years,and we can find the tendency of becoming younger.2. Tongue and gum are the most common sites successively as to OSCC. We can find the increasing tendency of tongue and cheek while gum decreasing during recent 10 years.3. Epithelial tumors are the most common in malignant oral-maxillofacial tumors,and the percentage are higher than other areas in our counry.4. Among salivary gland malignant tumors,the predilection sites are parotid gland ,Submandibular gland and palate gland by turns ;As to pathology type,the proportion of mucoepidermoid carcinoma is the most.5.There is association between smoking,alcoholic consumption,betel quid chewing and the incidence of oral mucosa squamous cell carcinoma.