Study On Correlations Of Subclinical Hypothyroidism With Coronary Artery Disease

Objective:To explore the correlation of subclinical hypothyroidism with coronary artery disease(CAD).Method:One hundred and forty-nine patients via coronary angiography were divided into two groups:normal coronary artery group(control group)and coronary artery stenosis group.Coronary artery stenosis group was further divided into two sub-groups,single-vessel coronary artery stenosis group and multi-vessel coronary artery stenosis group,according to the severity of CAD.Serum free triiodothyronine(FT₃),free thyroxine(FT₄) and thyrotropin(thyroid stimulating hormone)(TSH) were tested.Conventional risk factors of coronary artery disease (CAD), clinical characteristics, serum lipid levels, fibrinogen(Fbg) and angiographic results of coronary artery were also examined. Result:1.The prevalence of subclinical hypothyroidism in coronary artery stenosis group (21.7%)was higher than that in the control group(9%) (P<0.05).2.The prevalence of subclinical hypothyroidism in multi-vessel coronary artery stenosis group (28.6%) was higher than that in the control group(9%)(P<0.05).3.The concentration of sTSH in coronary artery stenosis group was higher than that in control group(P<0.05),and the concentration of sTSH in the multi-vessel coronary artery stenosis group was also higher than that in the single-vessel coronary artery stenosis group(P<0.05)and control group(P<0.01).4.Subclinical hypothyroidism was associated with coronary artery disease (OR=2.41 95% CI 0.91-6.38 ) ,and also correlated to multi-vessel coronary atherosclerosis(OR=2.93 95% CI 0.72-12.04).Conclusion:Subclinical hypothyroidism is one of the risk factors for the coronary artery disease .It has positive relationship with the severity of CAD.