Correlation Between Interleukin-1 In Cervical Intervertebral Discs With Degree Of Spinal Compression And Function Of The Cervical Spine Cord In Cervical Spondylotic Myelopathy

OBJECTIVE: To analyze the correlation between level of IL-1αand IL-1βin cervical intervertebral discs with degree of spinal compression and function of cervical spine cord, and to explore the effect of interleukin-1 on pathogenesis of cervical spondylotic myelopathy.DESIGN, TIME AND SETTING: The comparative observation experiment was performed at the Department of Orthopaedics, First Affiliated Hospital Anhui Medical University and the Laboratory of Department of Parasitology, Anhui Medical University from January to November 2008.PARTICIPANTS: A total of 48 intervertebral discs tissues from 25 patients with cervical spondylotic myelopathy enrolled in First Affiliated Hospital Anhui Medical University from January to October 2008 were collected. Twenty intervertebral discs of 10 inpatients with traumatic cervical injury were served as the control group. All samples were obtained from patients who underwent anterior neck surgery and donated voluntarily.METHODS: The contents of IL-1αand IL-1βin specimens were analyzed by ELISA method, the cervical spine cord function were measured by the Japanese Orthopesic Aesoliation (JOA) scoring system score before operation.MAIN OUTCOME MEASURES: The contents of IL-1αand IL-1βin intervertebral discs, the correlation between mass concentration of IL-1α/IL-1βof the cervical intervertebral discs and JOA scores and the correlation between degree of spinal compression and JOA in the experimental group were observed.RESULTS: All the cases were involved in the final analysis. The contents of IL-1αand IL-1βin experimental group were obvious increased compared with the control group (P < 0.01). There had a negative correlation between IL-1α, IL-1βand the JOA score in the experimental group (ra=-0.860, rb =-0.669, P < 0.01). There had incorrelation between degree of spinal compression and JOA in the experimental group .CONCLUSION: The contents of IL-1αand IL-1βin the cervical intervertebral discs of cervical spondylotic myelopathy are significant increased, which have a negative correlation with the JOA score. There had incorrelation between degree of spinal compression and JOA in the experimental group .