| Objective:To observe the therapeutic effect of Qing Xin Zi SHen method on patients suffering from perimenopausal insomina caused by Deficiency of Yin and Excess of Fire.Try to explore its potential mechanism.To provide scientific bases for the method of Qing Xin Zi SHen application in clinic.Method: 41 cases with perimenopausal insomina caused by Deficiency of Yin and Excess of Fire were randomly divided into 2 groups ,they're:30 cases in the treatment group and 15 cases in the control group.patients in the treatment group were given "Qing Xin Zi SHen Compound" for oral and in the control group were given "KUN TAI Capsule".The treatment period was 4 weeks.We observed the changes of the vary of the clinical symptoms' scores using Kupperman perimenpausal Scales and the scores of PSQI.Results: The totally effective rate of the treatment group was 90% and the control group was 73% with ststistical difference(P<0.05) Treatment group and control group PSQI, KMI score the overall effect of the existence of significant differences (P <0.01). PSQI one of the overall efficacy of the treatment group and control group difference is particularly evident, The overall efficiency of the treatment group has 97% efficiency of the control group 60% of the total that have heart medicine soup Zishen good effect to improve sleep. The total effective rate in treatment group 97%, onset time of the treatment group 6.8214±2.0377, control group, 10.1429±4.9747, that the treatment group effect quickly, there are differences (P <0.01).Conclution: Qing Xin Zi SHen could relief the clinical symptoms,keep the body in balance and improve life quality. Zi Yin Jiang Huo method could be regarded as one of effective ways in treatment of perimenopausal insomina.
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