The Clinical Observation Of Baoshensanhaofang Treating To Early-Medium Stage Of CRF

The paper includes two chapters, review and clinical research.The review part includes two parts. The first one reviewed the progress of modern research on chronic renal failure (CRF). It introduced the mechanism of progress and the non-hemodialysis. The second one is about Traditional Chinese Medicine(TCM) study on CRF, including the name of the disease, etiology, pathogenesis and the study of present treatment.The second part is the clinical research on CRF with BaoShenSanHao Decotion. OBJECTIVE: Tostudy the clinical effect of BaoShenSanHao Decotion in treatment of early-medium stage of CRF,and discuss the acting mechanism, for providing the useful methods of TCM to treat CRF.METHODS: 48 cases of CRF were collected according to the diagnostic standards of CRF inwestern medicine and syndrome differentiation in TCM, and randomly individed into two groups:the treat group(24) and the the control group(24). The treat group was treated with routin therapyand BaoShenSanHao Decotion. The another one was treated with conventional dose ofAngiotensin-converting enzyme inhibitors (ACEI) or angiotension II receptor blockers (ARB)besides the treatment of the treat group. 30 days is a therapeutic phase. And giving three phasesconsecutively. Then after treatment, checking the changing of effective indices such as clinicalsymptoms, renal function, electrolytes, blood lipids (triglyceride TG, cholesterol TC, high densitylipoprotein HDL, low density lipoprotein LDL), urine protein quantities of 24 hours (24hupd) ,hemoglobin(Hb), albumin(Alb) ect., and the safety indices in before and after therapy. RESULTS:The total effective rate of the treat group was 70.83%, and the control group was 79.19 % with nonesignificant difference(P>0.05), althought the later's effective rate was higher than the former. Thetwo groups could improve clinical symptoms, renal function, compared with pre-treatment withvery significant difference (P<0.01). The two groups could also increase hemoglobin, plasmaalbumin, high density lipoprotein and lower low-density lipoprotein, compared with pre-treatmentwith significant difference (P<0.05). After treatment, urinary protein decreased in the treat group,with significant difference (P<0.05); urinary protein also decreased in the control group with verysignificant difference(P <0.01). The level of calcium(Ca) was increasing, and the level ofphosphorus (P) was decreasing, but there was no significant difference (P>0.05). Compare to thecontrol group, all the effective indices of the treat group had no significant difference (P>0.05) aftertreatment. The safety indices also had no obviouse changes in before and after treatment.CONCLUSIONS: BaoShenSanHao Decotion had a good curative effect on early-medium stage ofCRF patients. It could improve the clinical symptoms and kidney function. It could reduce the levelof 24hupd, improve anemia, regulate protein-energy malnutrition, regulate dyslipidemia, regulationof calcium-phosphorus metabolism which had no significant difference in stastics. So futhur study would be needed to made. BaoShenSanHao Decotion had a well safety performance, and had no obvious poisonouse side effect.