Relationship Of Invasion With Expression Of VEGF,b-FGF In WHO Grade â… Meningiomas

Object Through monitoring the expressions of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(b-FGF)of WHO grade I〔《WHO(Year 2000) Classification》〕meningioma samples,we investigate the action of VEGF and b-FGF in the invasive behavior of meningiomas to offer theoretical and experimental evidence for clinical surgery,anti-angiogenic treatment,prognosis and relapse prevention of WHO grade I meningiomas.Methods The expressions of VEGF and b-FGF was determined by immunohistochemical technique in 50 WHO grade I meningiomas and 10 normal meningeals.We analyzed the relations between the expression levels of VEGF,b-FGF and the meningioma biological behaviors.The correlation between the expression levels of VEGF and b-FGF was also analyzed in this study.Results Expression of VEGF and b-FGF was negative in 10 samples of normal meningeal.Of 50 cases of WHO grade I meningioma,18 invaded the cerebral tissues adjacent to the tumors and 32 did not.In 18 cases of invasive meningiomas,there was strongly positive expression of VEGF in 13 cases,positive in 4,negative in 1 and the expression of b-FGF was positive in 14 and negative in 4.In 32 cases of noninvasive meningioma,there was strongly positive expression of VEGF in 2 cases,positive in 19 and negative in 11 and the expression of b-FGF was positive in 23 and negative in 9.There were significant differences in the positive and strongly positive rates of VEGF expression between the invasive and noninvasive meningiomas (P＜0.05).There was strongest expression of VEGF in the meningioma regions with the most evident invasion of the cerebral tissues.There was no statistical significance in the positive rates of b-FGF expression between the invasive and noninvasive meningiomas(P＞0.05).There was significantly positive correlation between the expression of VEGF and b-FGF in WHO grade I invasive meningiomas,WHO grade I noninvasive meningiomas and all 50 cases of WHO grade I meningioma(Spearman rank correlation coefficient are r_s=0.830,0.769,0.856,P＜0.01)Conclusions1.There was a close correlation between the expression of VEGF and the invasive behavior of WHO grade I meningiomas.It is suggested that the expression of VEGF may play an important role in the invasive behavior of WHO grade I meningiomas.The expression of VEGF can index the invasion of meningiomas and the prognosis of patient.2.There was no significance correlation between the expression of b-FGF and the invasive behavior of WHO grade I meningiomas.And it is suggested the expression of b-FGF plays a not so important role in the invasive behavior of WHO grade I meningiomas. 3.There was significantly positive correlation between the expression of VEGF and b-FGF in WHO grade I invasive meningiomas,WHO grade I noninvasive meningiomas and all 50 cases of WHO grade I meningioma.This suggested that there may be a mutual synergy between VEGF and b-FGF in occurrence and development of WHO grade I meningiomas.The study indicated the correlation between VEGF,b-FGF and invasion of WHO grade I meningiomas,and the expressions of VEGF and b-FGF had important significance in evaluation of the invasive behavior of WHO grade I meningiomas.Furthermore,this study offers theoretical and experimental evidence for clinical surgery, anti-angiogenic treatment,prognosis and relapse prevention of WHO grade I meningiomas.