The Efficacy And Adverse Reactions Of Different Doses Of Isoniazid Treatment In Tuberculous Meningitis

Objective:To confirm the clinical value and the adverse drug reaction between the two group patients given 0.6g/d or 0.9g/d isoniazid.Method:In our retrospective analysis ,a total of 109 patients with clinically diagnosed tuberculous meningitis were treated in our hospital from Sep 2004 to Feb 2008. Only the patients have typical clinical symptom,the cerebrospinal fluid abnormalities or the CT/MRI results can be included in our study. 41 patients were given 0.6g isoniazid per day.68 patients were given 0.9g isoniazid per day. All of the patients were given the other oral antituberculous drugs at the same time. Finally compare the clinical value and the adverse drug reaction between the two groups.Results: During the hospitalization, in the patients with nervous system damage, the effective rate of group A was 86.7%, group B was 77.8% (P>0.05).In the patients without nervous system damage, the effective rate of group A was 84.6%, group B was 97.6% (P>0.05). In the patients with nervous system damage, the improvement rate of CSF in the two groups was 72.7%,61.2%, respectively(P>0.05). In the patients without nervous system damage, the improvement rate of CSF in the two groups was 38.5%,84.2%, respectively(P<0.05)The ADR happened in both two groups, the incidence rate was 17.1%,36.8%, respectively (P<0.05). Conclusion : Increased the dose of drugs INH to increase its concentration in CSF, then it is more conducive to the resumption of CSF normal routine and biochemical. But different doses of INH treatment is nonsignificant in improvement of clinical symptoms during a short-term. It was found that with the dose of INH increased, the incidence of adverse reactions also increased. Therefore, while clinicians select the dose, they should be based on the patient's condition and consider the efficacy and adverse reactions carefully.