Study On The Chemical Constituents In CO₂-SFE Extract Of Alpinia Officinarum Hance

Alpinia officinarum Hance is one of commonly used traditional Chinese medicine,which is firstly recorded in Mingyi Bielu as medium grade.Gaoliang county, which now is the area of Zhanjiang in Guangdong Province Maoming City area produces it,so it is called Gaoliangjiang and recorded in the different versions of the Chinese Pharmacopoeia. Alpinia officinarum Hance belongs to the Zingiberaceae family, Alpinia genus. Radix Alpinia officinarum recorded in China Pharmacopoeia is the rhizome of Alpinia officinarum Hance (Zingiberaceae) which has been used as a traditional medicine in China for relieving stomachache, treating gastrofrigid vomiting, dyspepsia, invigorating the circulatory system, and reducing swellings. Modem researches suggested the chemical components of the crude drugs possessing antiplatelet, antioxidant, antiproliferative, anti-emetic, antihepatotoxic and anti-inflammatory activities. In order to make further chemical researches of the rhizomes of Alpinia officinarum, find active compounds and promote the modernization of this traditional Chinese medicine, a systemic phytochemical investigation has been carried out.Alpinia officinarum Hance main contains favonoids, volatile oil, diphenylheptane. Other ingredients have steroid, glycosides and phenylpropanoid compounds. Dozens of compounds have separated and identified as present.We have separated 8 monomer compounds from the CO2-SFE extract of Alpinia officinarum Hance by silica gel column chromatography and recrystallization, etc. On the basis of classical chemical methods and modern spectrometric approaches, including IR, CD, ¹HNMR, ¹³CNMR, ¹H-1HCOSY, HMQC, HMBC, NOESY, and EI-MS, etc., the structures of eight compounds among them were established.