The Dynamic Changes And Significance Of Serum NE,Hs-CRP In The Patients With Acute Intracerebral Hemorrhage

ObjectiveTo investigate the dynamic changes of blood serum NE (neutrophil elastase), Hs-CRP(hypersensitivity C-reactive protein) in the patients with acute intracerebral hemorrhage during the different phases of acute stage. Studying the relationship between the NE level and the volume of cerebral edema and the relationships between the levels of NE ,Hs-CRP and prognosis.MethodsThe essay was composed of 30 patients and 30 healthy people in the normal control group. All people had been hospitalized in the Department of Neurology, the first affiliated hospital of Soochow University between March 2008 and January 2009. Serum NE was serially determined by enzyme-linked immunosorbent assay(ELISA). Hs-CRP were measured by automatic biochemistry analyzer. WBC were determined by automatic blood analyzer. Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale(NIHSS)were recorded to assess the level of consciousness and neurological status on admission, and on follow-up visits (3 days, 7 days, 14 days). ICH and perihematomal edema volumes were measured on compute tomography.Results1 The serum level of WBC in ICH was increased at 24 hours. It was different between the group of ICH within 24 hours and at 14 days. In our study, we found the quantity of WBC had the decline tendency.2 There was a linear correlation between the quantity of WBC and the level of NE in the 4 study points (r=0.388).3 The serum level of NE increased within 24 hours. The highest level of NE was found at 3 days. NE level decreased dramatically after 7days. It returned to normal at 14 days.4 NE level at 24 hours was correlated to absolute perihematomal edema volume (P<0.05)and positively correlated to relative perihematomal edema volume(P<0.01).5 The NE level of the group in which the patients, condition aggravated is prominent higher than the group of improvement witin 24 hours.6 The level of NE was statistically correlated with GCS, NIHSS Hs-CRP. There were not correlations among NE levels and age, sex, the volume of hematoma, the blood pressure of 24 hours.7 The serum level of Hs-CRP increased dramatically at 24 hours. The level of Hs-CRP at 14 days was still higher than control group.8 The Hs-CRP level of aggravation group within 24 hours was not different from that of unchanged group and improvement group.Conclusions1 There is the abnormal metabolism of NE in ICH patients. Our investigation indicates the temporal profile of NE. Serum NE level after spontaneous intracerebral hemorrhage may be the index of predicting the severity of perihematomal edema volumes.2 Serum NE level at 24 hours is positively correlated to the alteration of patients'condition. Monitoring serum NE level may contribute to predict clinical outcome.