Observation Of The Short-term Therapeutic Effectiveness Of Body γ-knife In 62 Patients Of Stage Ⅰ And Ⅱ Non-small Cell Lung Cancer

Objective: The main methods of non-small cell lung cancer (NSCLC) treated are operation and radiotherapy.The past clinical effect proved that operation was the most effectest method. The survival rate in five year of NSCLC in stage I and II treated is 50%~70%. But when the patients visit the doctor,only the 30% can be operated.Although the early stage of NSCLC which treated by operation is better than which treated by radiotherapy,The two can not compared to the other.The patients who are with old age or cardiorespiratory function wich can not toleranted by operation can only treated by radiotherapy. But the survival rate in five year of the NSCLC in stage I treated by the common radiotherapy is only 10%~30%。The control rate of the part on tumour is only 50%,The reason which the therapeutic effect of the common radiotherapy is low is the low part contorl rate.So we can see that to raise the control rate of the part on tumour is the one of the way to raise the survival rate for long time to the patient. Presently, concomitancing with the development of the radiotherapy,there appear a lot of method of Stereotactic hypofractionated radiation therapy(SRT). Bodyγ-knife is a novel cancer treatment strategy in the late twentieth century practice of clinical radiation oncology of our country. Contrast to the common radiotherapy, Bodyγ-knife have lots of virtue.for example the dose to the tumor is high and the injury to the normal tissue is low ,and so on.The study is to observe therapeutic effect and adverse reaction when bodyγ-knife treat NSCLC in stage I and II. Methods: sixty-two patients with NSCLC in stage I and II were treated with OUR-QGD type Stereo tactic Radiotherapy Gamma Rays System. Dose Curve of this group of cases is 50%. Encircled dose of carcinoma which are less than or equal to 50 % is 5 Gy per fraction, The range of total dose is 40-50Gy. The course of treatment is total 2-4 weeks.Majority of the patients are treated every other day.Results: After 3 months with SRT, 62 cases are checked by CT again. CR is 56%, PR is 35%, SD is 8%,PD is none.CR+PR is 92%.The rate of local concorled in 1,2,3 years is separately 92%,92%,92%,and the rate of survival in 1,2,3 years is separately 89%,84%,82%。Conclusion: Bodyγ-knife is an effective cancer treatment strategy using to be administered to the NSCLC in stage I and II which can not treat by operation. Treating Advanced PC with SRT ensures that NSCLC get exact high-dose radiation, with little damage to the normal tissues nearby. SRT has provided clinical radiotherapists with a safe and efficient treatment method. Bodyγ-knife adopting high dose per fraction and short-course of treatment saves time for patients to accept other cancer treatment strategy.