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Clinical Study On Treatment Of Knee Osteoarthritis Of The Kidney Empty Marrow Owesstasis By Warming Needle Moxibustion

Posted on:2010-02-03Degree:MasterType:Thesis
Country:ChinaCandidate:X XuFull Text:PDF
GTID:2144360278450821Subject:Acupuncture and Massage
Abstract/Summary:PDF Full Text Request
Objective:The investigation is to observe the therapy effect on warm needle moxibustion for knee osteoarthritis of The kidney empty marrow owesstasis,meanwhile to compare the result treating KOA with the treatment of warm needle moxibustion and the treatment of medium frequency electrotherapy.Moreover to expound the changes of matrix metalloproteinase-3 (MMP-3),nitrogen monoxide(NO),tumor necrosis factor-a(TNF-a) and bai Jiesu-1(IL-1) before and after treatment,in order to discuss warm needle moxibustion mechanism on KOA,in order to provde a better way to treat KOA.Methods:(1) Received object:According to the diagnosis standard made by Rheumatism Association of American and the latest clinic diagnosis standard had already reported,the data have 67 cases of orthopedics,include clinical and hospitalized patients,who were selected from 2007.10-2008.12 of the second traditional Chinese medicine hospital of fujian.32 male patients and 35 female patients,age from 45 to 75 years,average age is 65 years.(2) Cases subgroup:67 cases of patients with knee osteoarthritis were randomly allocated into two different therapeutic groups:warm needle moxibustion group(A group),medium frequency electrotherapy group(B group).(3) Operation Method:A group selects neixiyan and waixiyan as chief acupoints and combines with warming needle moxibustion on the acupoints,B group adopts medium frequency electrotherapy.The patients of two groups were all treated one time everyday and 15 days were a course of treatment and they had take a rest for 2 days between two courses,three courses in total. All patients are prohibited to use any other KOA medicine during treatment period.(4) Detect marker:Before the treatment and after three courses of treatment,we evaluated respectively the clinic symptoms scores of two groups,meanwhile measure the contents of synovial fluid MMP-3, NO,TNF-a and IL-1 before and after treatment.Then we analyze the clinic symptoms scores and synovial fluid MMP-3,NO,TNF-a and IL-1 concentrations throuth statistics,in order to observe the therapeutie effcacy on warm needle moxibustion for KOA and change situation of synovial fluid MMP-3,NO,TNF-a and IL-1.(5) Data processing:Experimental data are analyzed with software Spss.13.0.Results:(1) After three course of therapy,two methods all can improve KOA clinical symtoms.But by contrast,A group was better than B group in improving clinical symptoms(P<0.05),(2) A relevant analysis of the clinic symptoms scores and synovial fluid MMP-3 concentrations of the two groups,there was a significantly positive inter-relationship between the clinic symptoms scores of patients with knee osteoarthritis and synovial fluid MMP-3 concentrations(related coefficient is 0.721,P<0.05),(3) A relevant analysis of the clinic symptoms scores and synovial fluid NO concentrations of the two groups,there was a significantly positive inter-relationship between the clinic symptoms scores of patients with knee osteoarthritis and synovial fluid NO concentrations(related coefficient is 0.700,P<0.05);(4) A relevant analysis of the clinic symptoms scores and synovial fluid TNF-a concentrations of the two groups,there was a significantly positive inter-relationship between the clinic symptoms scores of patients with knee osteoarthritis and synovial fluid TNF-a concentrations(related coefficient is 0.742,P<0.05),(5) A relevant analysis of the clinic symptoms scores and synovial fluid IL-1 concentrations of the two groups,there was a significantly positive inter-relationship between the clinic symptoms scores of patients with knee osteoarthritis and synovial fluid IL-1 concentrations(related coefficient is 0.660,P<0.05),(6) Statistics comparison of the contents of synovial fluid MMP-3 before and after treatment,two methods all can decrease synovial fluid MMP-3 concentrations effctively.But by contrast,A group was better than B group(P<0.05),(7) Statistics comparison of the contents of synovial fluid NO before and after treatment,two methods all can decrease synovial fluid NO concentrations effctively.But by contrast,A group was better than B group(P<0.05),(8) Statistics comparison of the contents of synovial fluid TNF-a before and after treatment,two methods all can decrease synovial fluid TNF-a concentrations effctively. But by contrast,A group was better than B group(P<0.05),(9) Statistics comparison of the contents of synovial fluid IL-1 before and after treatment,two methods all can decrease synovial fluid IL-1 concentrations effctively.But by contrast,A group was better than B group(P<0.05).Conclusion:(1) The efficience of warm needle moxibustion is 93.33%.The efficience of Intermediate frequency is 73.33%,the result demonstrates that warm needle moxibustion is better another group,(2) The warm acupuncture group improves the clinical symptoms obviously,the alleviation ache,so the warm acupuncture is quite effective method to treat the The kidney empty marrow owesstasis knee osseous arthritis,(2) KOA synovial fluid MMP-3,NO,TNF-a and IL-1 level are correctable with KOA clinical symptoms,(3) Through measuring the contents of synovial fluid MMP-3,NO,TNF-a and IL-1 before and after treatment,the result demonstrates that two ways all can decrease synovial fluid MMP-3,NO,TNF-a and IL-1 level,but warm needle moxibustion is better another group.According the effective therapy by warm needle moxibustion, we maybe achieve the purpose of protecting articular and recovering KOA of The kidney empty marrow owesstasis.
Keywords/Search Tags:Knee Osteoarthritis/Acup-Mox Therapy, Warm needle moxibustion/The kidney empty marrow owesstasis, MMP-3/NO/TNF-a/IL-1
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