The Research Of The Relationship Between The Disorder Of Serum Lipids, Oxidative Stress And Acute Cerebral Infarction In The Group Of Aged Patients Who Exceed 70 Years Old

ObjectiveTo detect the change of serum lipids , plasma oxidized low density lipoprotein (oxLDL) and 8 Isoprostan Prostaglandin F2alpha (8-iso-PGF_2α) after cerebral infarction in the group of the aged person who exceed 70 years old and to investigate the relationship between the level of plasma oxLDL and 8-iso-PGF_2α after cerebral infarction and the size of infarction,the NIHSS score .To compare the difference of the level of plasma oxLDL and 8-iso-PGF_2α between the group of the aged patients who exceed 70 years old and are less than 70 years old after cerebral infarction. Then to discuss the effect of oxidative stress and lipid peroxidation on the development and progression of cerebral infarction patients who exceed 70 years old.To research the change of plasma oxLDL and 8-iso-PGF_2α before and after antioxygen therapy. Then to discuss the effect of antioxygen therapy on the treatment of cerebral infarction patients who exceed 70 years old and to provide the evidence for the treatment of cerebral infarction.Methods29 patients with cerebral infarction who exceed 70 years old were chosen as case group and there were 30 patients with cerebral infarction who are less than 70 years old as internal control. In addition,another 29 healthy ages(>70 years old) as normal control. Serum total cholesterol (TC), triglyeride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (APOA1) , apolipoprotein B (APOB), lipoprotain(a) [Lp(a)] and UA were assayed in all cases and 8-iso-PGF_2α and oxLDL were detected with ELISA in all cases.All datas were compared and analysed between groups.Results1. The concentration of TC, TG, LDL- C , oxLDL and 8-iso-PGF_2α in the case group and the internal group was higher than that of the normal group(P<0.05).2. There is a positive correlation between the level of plasma oxLDL and 8-iso-PGF_2α.3. Compared with the group who are less than 70 years old, the concentration of 8-iso-PGF_2α and oxLDL was higher in the group who exceed 70 years old (P<0.05), however, the concentration of TC and LDL-C was lower in the group exceed 70 years old (P<0.05).4. Compared with the normal group,the level of serum UA was higher in both the group who exceed 70 years old and are less than 70 years old.There was no significant difference of the level of serum UA between the group who exceed 70 years old and are less than 70 years old.ConclusionThe disorder of serum lipids increases the risk of the development of cerebral infarction and the increasing of oxidative stress and lipid peroxidation promotes the initiation and progression of cerebral infarction. Compared with common adults, the level of serum lipids inclines to decrease in the group of the aged who exceed 70 years old, but the level of lipid peroxidation and oxidative stress increases after the initiation of cerebral infarction.