Morphological Characteristics And Immunohistochemical Expression Of The Sarcomatoid Cancer

Objective: To discuss the standard of sarcomatoid cancer diagnosis by observing the sarcomatoid cancer pathology and morphological characteristics and immuno- histochemical expression。Methods: After taking HE staining methods and Immunohistochemistry with sarco- matoid cancer of the immune phenotype to tag, observing sarcomatoid cancer of mor- phological characteristics by the light microscopy。Results: 1. Sarcomatoid cancer widely distributed can occur in many locations, and can be found in almost all types of cancer;2. Sarcomatoid cancer, in the skin or mucous membrane, look like polypus, and can be expressed as various types of sarcomatoid images.3. various types of cancer images can be expressed such as①Large piece of well differentiation ,②Can only showed intraepithelial neoplasia without the element of cancer,③Some of the element of cancer,④Some cases could not find cancer in the microscope;4.Sarcomatoid cancer of the immune phenotype, the element of cancer have no spe- cial immune phenotype with CK and EMA (+) and sarcomatoid immune phenotype of complex and varied CK (AE1/AE2) (+) 25.8%, EMA (+) 17.9%. Des (+)2.2%,SMA (+)32.5%,S-100 (+)4.9%,CD34 (+)35.6%,E-cad (+)26.7%,HMB45 (+)0%及Vim (+)100%. Conclusion: 1.Sarcomatoid cancer have complex morphology structure, diversity performance and complicated immune phenotype.2.Diagnostic criteria:①Sarcoma-like structure is observed in the site of cancer occurred should take into account sarcomatoid cancer; after completely excluding sarcomatoid cancer, maybe be diagnosed as sarcoma,②Sarcomatoid elements >50%, if the ratio of tissue sarcoma is too small for easy diagnosis of cancer,③Pay attention to the diagnosis of many subjects should be carefully looking for cancer, carcinoma in situ and non-typical elements, in particular, to find transitional region between the two,④CK, EMA positive expression should not alone be used as sarcomatoid cancer diagnosed.