Retrospective Study Of The Relevant Risk Factors In The Cerebral Infarction Patients With Intra/extra-cranial Artherosclerosis

Purpose It is generally acknowledged that age,sex,obesity,hypertension,diabetes, hyperlipidemia,coronary artery disease,smoke and alcoholism are risk factors of ischemic stroke.This study is aimed to evaluate the distribution of these risk factors among the stroke patients with or without large artery artherosclerosis intracerebral/extracerebral.Method Patients with ischemia stroke admitted to neurology department of Huashan hospital were reviewed with their data,including general information,medical history,risk factors of stroke and angiographic images;According to the angiographic images,the patients were classified into subtypes as lacunar stroke,large artery artherosclerosis stroke, stroke with none-criminal artery artherosclerosis,stroke with criminal artery artherosclerosis,stroke with intracranial criminal artery artherosclerosis and stroke with extracranial criminal artery artherosclerosis.Risk factor differences among subtypes were examined with the x~2 test or CMH x~2 test for significance.The multiple logistic regression analysis was also employed to evaluate the interrelationship among subtypes and risk factors.Results Of 304 patients,there were 95 lacunar stroke patients and 209 LAA-s patients,which included 47 None-CAA-s patients and 162 CAA-s patients;In the group of CAA-s patients,there were more ICAA-s patients(55.56%) than ECAA-s(44.44%) ones.Between Lac-s and LAA-s,increased risk for LAA-s was associated with the age(＞65y)(P=0.018,OR=2.07),smoke(P=0.013,OR=2.33) and hyperglycemia(P=0.005, OR=1.57);With patients above the age of 65,the risk for large artery artherosclerosis stroke was twice that of lacunar stroke;With smokers,the risk for large artery artherosclerosis stroke was 2.3 times that of lacunar stroke;With patients of hyperglycemia,the risk for large artery artherosclerosis stroke was 1.5 times that of lacunar stroke;However,other target risk factors didn't show significant differences,and neither did all factors between None-CAA-s and CAA-s(P＞0.05).Between ECAA-s and ICAA-s,decreased risk for ICAA-s was associated with male(P=0.001,OR=0.15),and increased risk for ICAA-s was associated with hyperglycemia(P=0.012,OR=2.61),none the less,diabetes didn't raise the risk for either subtype(P＞0.05).Conclusion Risk factors like age(above 65),smoking and hyperglycemia would increase the danger for large artery artherosclerosis stroke,compared with lacunar stroke. Other stroke risk factors,such as sex,obesity,history of coronary artery disease and stroke, hypertension,serum lipid sequence abnormal,did not make much difference between lacunar stroke and large artery artherosclerosis stroke.There was no significant diversity between strokes with and without criminal artery artherosclerosis.The male members are more likely to suffer from stroke with extracranial artery artherosclerosis,while hyperglycemia sufferers tend to catch stroke with intracranial artery artherosclerosis.