Jiakangpingxiao Pills Treats The Thyroid Function Hyperfunction (Graves Disease) Sickness Experimental Study

Objective: Observes Jiakangpingxiao pills to the thyroid function hyperfunction model big mouse overall situation, blood serum TT3, TT4, the TSH level, thyroid gland related immune body TGAb, the TMAb examination level influence, as well as to target and so on thyroid gland pathology organization pathology change observations, analyzes Jiakangpingxiao pills to the GD big mouse model influence, carries on the appraisal to its health giving quality and the security, treats the thyroid function hyperfunction sickness take the time as clinical utilization this Fang Ji to provide the powerful experiment basis and the more comprehensive system's theory basis, and treats own immunological disease for the Chinese medicine to provide the mentality. Method: Female SD big mouse 70, divide into stochastically:①Blank group;②Model group;③High monitoring team;④Monitoring team;⑤Low monitoring team;⑥tapazole group;⑦Jiakangpingxiao pills merges the Tapazol group, each group of 10. Besides the blank group, each group uses the thyroid gland piece according to the 1.25mg/100g body weight, fills the stomach to make the mold to the medicine way 4 weeks. Makes mold period, every day observes big situations regularly and so on mouse's psychic reaction, activity, diet, hair, excrement. After making the mold had finished, besides the blank group and the model group, each group carries on treatment in January. Observes the big mouse ordinary circumstances the change, after the experiment ended, takes the big mouse circumference blood and the thyroid gland organization, determination blood serum TT3, TT4, the TSH level, blood serum thyroid gland related immune body TGAb, the TMAb examination level influence, as well as to thyroid gland pathology organization pathology change.Results: 1. According to the related literature's method manufacture thyroid function hyperfunction big mouse model, the model group big mouse performance is the behavior change, lose weight, rise of bodily temperature, blood serum TT3, TT4 elevates, TSH reduces, serum antibody TGAb, TMAb the level elevates, the thyroid gland organization occurs conforms to the thyroid function hyperfunction sickness organization pathology change, proved that duplicates this thyroid function hyperfunction big mouse model to be successful.2. After the treatment, each treatment group is improving the big mouse outward appearance behavior, puts on weight, reduces the big mouse body temperature, reduces big mouse blood serum TT3, TT4, elevates the blood serum TSH level, compares with the model group, has the remarkable difference. Reduces serum antibody TGAb, the TMAb horizontal aspect to have the good curative effect, compares with the model group, has the difference. Jiakangpingxiao pills high monitoring team, Tapazol group in improvement blood serum TT3, TT4 aspect curative effect quite, but Jiakangpingxiao pills merges the Tapazol group in the improvement blood serum TSH aspect curative effect well in Jiakangpingxiao pills high monitoring team, in Jiakangpingxiao pills monitoring team and Tapazol group.3. Jiakangpingxiao pills may reduce the thyroid gland related antibody titer, has the adjustment unusual thyroid gland related immune body (TGAb, TMAb) the function, has the immunity adjustment function, Jiakangpingxiao pills to gather the Tapazole group and the model group evenly has the difference (p<0.01). Other each group and the model group does not have the significance difference (p>0.05). But compares with the blank group, Jiakangpingxiao pills to gather the Tapazole group evenly to be closest with it, statistics non-significance difference (p>0.05). Jiakangpingxiao pills high dose, Jiakangpingxiao pills the monitoring team and the blank group has the difference (p<0.05). The Tapazol group, Jiakangpingxiao pills the low monitoring team and the blank group has the significance difference (p<0.01). Conclusion: The experimental result prompts Jiakangpingxiao pills to be possible to improve the thyroid function hyperfunction big mouse ordinary circumstances effectively, increases its body weight; Reduces the thyroid function hyperfunction big mouse body temperature, reduces in the thyroid function hyperfunction big mouse blood the thyroxine and the thyroid gland related immune body level, improves the thyroid gland pathology organization shape, prompts Jiakangpingxiao pills to have suppresses certainly the thyroid function the function. But the overall, the pure traditional Chinese medicine treatment result was inferior that the traditional Chinese medicine and the western medicine union treatment, prompts Jiakangpingxiao pills to come in handy with Tapazole has the synergism, treats the thyroid function hyperfunction curative effect to affirm, may reduce the improvement symptom the time, the reduced western medicine amount used, to reduce the western medicine side effect. But merges the Tapazol group effect by Jiakangpingxiao pills to be most superior, explained that Jiakangpingxiao pills merges the Tapazole group traditional Chinese medicine ingredient and Tapazole's proportion disposition is more appropriate, is worth the clinical promotion.