Artificial Liver Therapy To Heavy Hepatitis Chinese Medicine Various Cards Curative Effect Observation

Objective:Observed for liver treatment in patients with severe hepatitis permit the distribution of Chinese medicine,evidence-based analysis of the liver before and after treatment in patients with liver function(ALT,AST,TBil),coagulation(PTA),electrolytes (Na~+,K~+),blood Conventional(WBC,PLT) and other indicators of changes in liver after treatment and the evidence-based efficiency and overall mortality compared to study the therapy of severe hepatitis with artificial liver of the syndrome types of TCM curative effects.Methods:Cases were selected from 279 cases of liver disease in Hubei Branch of Chinese medicine hospitals from January 2002 to August 2008 out-patient and in-patient departments,are consistent with the diagnosis in 2000(Xi'an) of the Sixth National study of infectious and parasitic diseases conference revised diagnostic criteria for viral hepatitis.Selection of 147 cases of liver treatment in patients with severe hepatitis as the treatment group, randomly selected in the same period without artificial liver treatment in patients with 132 cases of severe hepatitis as a control group,two groups in age,disease,sex,previous treatment history,evidence-based distribution of a number of indicators such as no significant difference(P> 0.05),comparable.Two groups of patients are bed rest,into digestible diet,add sufficient energy,ban alcohol,to avoid the application of harmful substances on the liver,liver treatment basis.Conventional application of vitamin K1,reduced glutathione,diammonium glycyrrhizinate,compound amino acid,potassium-magnesium aspartate,such as antibiotics,at the same time the application of TCN treatment,such as the use of clearing heat and detoxication, advantage draws back wet yellow,invigorates the blood the supple liver,sparse liver and strong spleen.Regular replenishment of albumin,plasma and other blood products,prevents and controls the complication positively.Treatment group were liver(plasma exchange) in the treatment of every 5 - 7 days improved to stable condition.Cases the treatment of every 1 to 5 times.Artificial liver in treatment group before and after treatment check liver function,electrolytes,blood conventional,blood coagulation, such as a full set of indicators(refer to do pre-treatment liver liver indicators at the time of the blood,liver liver after treatment means 60 days after the blood indicators),observed after the treatment of liver-type card and the overall efficiency of the comparison of mortality rates.SPSS16.0 software used for statistical analysis,measurement data to mean±standard deviation of that normal distribution between the two groups were compared using t test,non-normal distribution to compare the two groups using rank sum test,X2 test the use of count data testing standards forα= 0.05 as the standard,P≤0.05 considered significant difference. Results:1.Efficacy analysis:the treatment group and control group after the treatment efficacy of evidence-based comparison:Liver depression and spleen deficiency type,Obstructs abundantly hot and damp type,Uepatorenal Yin deficient type,Spleen kidney deficiency of yang type efficacy of the treatment group was superior to the control group,Reduqing Flourishing type the two groups before and after treatment was no significant difference in efficacy;Liver depression and spleen deficiency type,Obstructs abundantly hot and damp type,Reduqing Flourishing type,Hepatorenal Yin deficient type,Spleen kidney deficiency of yang type prognosis of the treatment group were significantly better than the control group.2.On the effects of laboratory indicators:Liver depression and spleen deficiency type,Obstructs abundantly hot and damp type,Reduqing Flourishing type,Hepatorenal Yin deficient type treated group of patients with ALT,AST,TBil indicators than before treatment has significantly improved(P <0.05),Liver depression and spleen deficiency type,Obstructs abundantly hot and damp type, humid ALB,DBil indicators than the pre-treatment also significantly,improved(P <0.05),electrolyte and blood indicators were not significantly improved.And Spleen kidney deficiency of yang type only treatment group TBil,WBC indicators than before treatment has significantly improved(P <0.05),consider the example of a small number of possible cause,nor to exclude the evidence-based treatment in itself is not sensitive to the liver.Conclusion:This research divides the heavy hepatitis into Liver depression and spleen deficiency type,Obstructs abundantly hot and damp type,Reduqing Flourishing type,Hepatorenal Yin deficient type, Spleen kidney deficiency of yang type,with domestic related report basic match case.Severe hepatitis with artificial liver therapy on Chinese medicine of Liver depression and spleen deficiency type, Obstructs abundantly hot and damp type,Reduqing Flourishing type,Hepatorenal Yin deficient type are effective,Liver depression and spleen deficiency type,Obstructs abundantly hot and damp type are more effective than Reduqing Flourishing type,Hepatorenal Yin deficient type,but Liver depression and spleen deficiency type is significant difference with Obstructs abundantly hot and damp type,Reduqing Flourishing type is significant difference with Hepatorenal Yin deficient type. Spleen kidney deficiency of yang type not seen a marked improvement after treatment.Liver depression and spleen deficiency type, Obstructs abundantly hot and damp type,Reduqing Flourishing type,Hepatorenal Yin deficient type Prognosis of the treatment group were significantly better than the control group.