Study Of Brain Natriuretic Peptide On Early Diagnosis And Prognosis Of Cor Pulmonale In Elderly Patients

Objective To study brain natriuretic peptide on early diagnosis and prognosis of cor pulmonale in elderly patients.Methods 120 cases geriatric patients with COPD were divided into four groups according to mean pulmonary artery pressure(MPAP) level after given ultrasonic Doppler echocardiography examination,that were group A which patients were with normal MPAP level;group B which patients were with increased MPAP level; group C which patients were with PHD in remission stage and group D which patients were with PHD in acute stage.Blood samples were draw from every patient to determine the plasma level of brain natriuretic peptide and PaO₂ and PaCO₂.The follow-ups were conducted in 12 months to observe the incidence of re-hospitalization.One-Way ANOVA and regression were used in analyzed the correlation between pulmonary hypertension and plasma level of brain natriuretic peptide and Kaplan-meier and COX regression were used in evaluated the prognostic value of plasma level of brain natriuretic peptide on pulmonary heart disease in elderly patients.All data were analyzed by SPSS 15.0 statistical software.Results The plasma levels of brain natriuretic peptide were significant differences among groups which were 30 patients respectively(P＜0.01).There were linear regression relationship between plasma levels of brain natriuretic peptide and PaO2,MPAP,RVOT,RVD,RVAWT in elderly patients statistically(r=0.970,P＜0.01).Cox regression survival analysis also showed that there was linear regression relationship between plasma levels of brain natriuretic peptide and the incidence of re-hospitalization in elderly patients with cor pulmonale(regression coefficient=0.044;wald=11.552;p＜0.01).Kaplan-meier analysis showed that the patients whose plasma levels of brain natriuretic peptide were more than 80ng/L had worse prognosis than the patients whose BNP plasma levels were less than 80ng/L.Conclusions Higher plasma level of brain natriuretic peptide has prognostic and early diagnostic values in elderly patients with cor pulmonale.