Neurokinin A Level In Hypoxic-ischemic Encephalopathy

Objective:The present study was performed to investigate the effect of neonatal hypoxic– ischemic encephalopathy(HIE) on the neurotransmitter neurokinin A (NKA) and determine its relation to the severity of neonatal hypoxia.Methods:We detected the level of serum NKA by ELISA in 30 HIE and 14 control full-term infants, collecting the clinical information.Results:①The serum level of NKA in control group was 4.33±0.73ng/L. The level of NKA in mild HIE group was 3.80±0.55ng/L whereas that of moderate HIE group was 1.65±0.45ng/L and severe HIE group was 0.80±0.31 ng/L in the acute period. There was significant difference among them (P<0.01).②The serum level of NKA in convalescent was 4.08±0.46ng/L, moderate HIE group was 2.41±0.53ng/L and severe HIE group was 1.23±0.26ng/L in the convalescent. Each group of serum NKA level has statistics significance difference among them (P<0.01).③The serum value of NKA of mild HIE group in recovery period was higher in acute period ,but there was no significant difference statistically significant (P> 0.05). The density of NKA in moderate,severe HIE group in recovery period was significantly higher in acute period. There was significant difference between them (P<0.01).Conclusion:①The serum level of NKA in HIE patients are lower obviously than non-HIE groups, which shows that it participated in the pathphysiological process of neonate hypoxic-ischemic encephalopathy.②There are close relationships between the change of NKA and the patient's condition, course of disease. It is significant to supervise the trends of NKA for judging the state of disease and directing treatment.③It is simple, accurate, less blood and distinctive to test the level NKA in HIE patients with ELISA which has practical value in clinical work.