Clinical Research On Cognitive Function Impairment After Acute Cerebral Infarction

Objective:To assess cognitive function after acute cerebral infarction combination of neuroimaging,neuropsychological tests and Event-Related Potential P300,to explore characteristics of cognitive impairment in acute cerebral infarction,and to analyze the relationship between infarction sites and acute cerebral infarction after the cognitive impairment.Methods:We select 134 cases of first acute cerebral infarction patients and 50 healthy control subjects matches with age,sex,and education level.All subjects were examined with Mini-mental State Examination(MMSE),Clinical Memory Scale(CMS),Verbal Fluency Test(VFT),Clock Drawing Task(CDT),Daily Living Skills Assessment(BI),Hachinski Ischemic Scole(HIS),Hamilton Depression Scale(HAMD).Patients and healthy control subjects were examined event-related potentials P300 testing on the same day or the following day.The above results of neuropsychological assessment scales and P300 findings in accordance with the typing of cerebral infaction comparing images reseach and related reseach.Results:1.Acute cerebral infarction in patients has the occurrence rate of cognitive function impairment significantly higher than the normal control group.2.The score of MMSE,CMS,VFT,CDT in acute cerebral infarction were significantly lower than the control group,the amplitude of P300 were significantly lower than the control group,the latency of P300 was significantly longer than those in the control group,the difference provides the statistical significance.3.The score of MMSE,CMS,VFT.CDT in middle infarction were lower than small infarction and lacunar infarction,the score of MMSE,CMS, VFT,CDT in small infarction were lower than lacunar infarction,the difference provides the statistical significance in the score of MMSE,CMS,VFT,CDT between middle infarction and lacunar infarction;There was no statistically significant difference in the score of MMSE, CMS,VFT,CDT between middle infarction and small infarction,small infarction and lacunar infarction.4.Further study based on infarction sites,we divided middle infarction,small infarction and lacunar infarction into subgroups:(1)Middle infarction and small infarction subgroup show:The score of MMSE,CMS in frontal lobe infarction and temporal lobe infarction are lower than basal ganglia infarction and apica lobe infarction,occipital lobe infarction,the score of MMSE,CMS in basal ganglia infarction are lower than apica lobe infarction and occipital lobe infarction,both statistically significant difference;The score of VFT,CDT in frontal lobe infarction was significantly lower than the temporal lobe infarction,apica lobe infarction,occipital lobe infarction and basal ganglia infarction,the difference provides the statistical significance.(2) Lacunar infarction subgroup show:there was no statistically significant difference in the scole of MMSE,CMS,VFT.CDT among temporal lobe infarction,apica lobe infarction,occipital lobe infarction and basal ganglia infarction.5.The sub-item score of MMSE comparison with the normal control group:The sub-item score of MMSE in acute cerebral infarction were lower than the control group,in particular the score of implementation capacity,attention and memory function was significantly lower than the control group,the difference provides the statistical significance.Conclusions:1.Cognitive impairment after acute cerebral infarction are common complications.2.There is closely related between neuroimaging classification and cognitive impairment in acute cerebral infarction.There is related between cognitive function impairment and infarction sites in the subgroup of middle infarction and small infarction.the frontal lobe infarction and the temporal lobe infarction are the most obvious in impaired cognitive function,followed by basal ganglia infarction,once again are the apica lobe infarction and the occipital lobe infarction:There is no relation between cognitive function impairment and infarction sites in the subgroup of lacunar infarction.3.The patients in acute cerebral infarction maily injury implementation capacity,attention and memory function.4. P300 event-related potentials can be used to achieve greater precision and sensitivity in cognitive evaluation in patients with acute cerebral infarction.