The Prevalence Study On The Human Papilloma Viruses (HPV) Infection Of The Community Female Population In Hongkou District

Objective:To investigate the prevalence of human papilloma viruses(HPV) in community population and make a comprehension of the infectious rate,type, people's cognition of HPV vaccine.To analysis the high risk of HPV infection and accumulate basic data for primary prevention(vaccine) on cervical cancer.Methods:A cross sectional study with random cluster sampling was given in Hongkou district from January 2007,the subjects was sampled in residential women age between 16-54,in two communities.Women with cervical cancer,hysterectomies history,pelvic cavity radiotherapy history,pregnancy are excluded.After consent,all eligible women were given an epidemical questionnaire and 997 women finished the questionnaire.Exfoliated cervical cell samples were collected in women with sexual life for both Liquid-based cytology(LCT) and HPVDNA hc2 test.Perineum biopsies were given to women without sexual life according to their aspirations and the samples underwent the HPVDNA hc2 test.Subjects with both LCT and HPVDNA positive test results were given the colposcope biopsy and the pathology diagnosis. VFP was used to set up the data base,SPSS13.0 was used to analysis the data with x~2 test,logistic regression was used for multi-factor analysis.Results:950 women finished the HPVDNA and LCT screening,the pathology test showed that in subjects with both LCT and HPVDNA positive test results,there are 1 case cervical infiltrating carcinoma(2.2%),4 cases CIN3(8.7%),6 cases CIN2 (13.0%),and 8 cases CIN1(17.4%).HPV-H(hc2) detection rate in the population was 11.86%which was lower than the national rate(14.2%).The rate of≤30 age group was lower(8.93%,9.3%),rates of 31-35 and 41-45 were higher(15.13%and 16.28%),double peak was observed in the infection curve.3 variables entered the multi-factors model:times of marriage,whether using condom in sexual life,the last pregnant age.The risk of HPV-H infection is 0.271(0.114—0.645) times in unmarried women than women who married for 2 times,that means unmarried is a protective factor for HPV-H infection.Women who didn't use condoms in sexual life had a high risk of HPV-H infection,which is 1.787(1.000—3.193) times than women who did.Not using condom in sexual life is a risk factor.Age of last pregnant is a protective factor,pregnant age increased for 1 year followed with a 0.927 times of risk on HPV-H infection.20.6%of subjects had heard of HPV,the knowledge is poorer in age group of 16-20,just 4.9%,than other groups.53.2%of subjects were aware of the link of cervical cancer and HPV;66.89%thought that HPV was a risk factor;66.1%will have the HPV vaccine inoculation,the rate is 81.4%in age group of 26-30,≤20 age group had the lowest rate of 60%.53.64%of mothers in this study were willing to have their daughters receive the HPV vaccine inoculation.Women don't want have HPV vaccine inoculation had the reasons as follows:don't think they have the risk of HPV infection;HPV vaccine is not generalized;the source of HPV vaccine is not trustful,the rate are all higher than 60%.96.7%of women who want the vaccine thought they would benefited from the vaccine.98.2%of subjects hoped that HPV vaccine can prevent cervical cancer,64.7%hoped to prevent Genital wart. The source of HPV vaccine subjects can accepted were government(65.0%) and hospital(32.6%);63.3%of people hope the effective power of HPV vaccine was 100%.The hoped average age of HPV vaccine inoculation was 21,and people hope that government could pay for the whole cost of HPV vaccine.38.0%of subjects choose to pay for the HPV vaccine if the cost is lower than 20 yuan.Only 6.1%will pay for the vaccine if the cost is higher than 100.The proper prize of HPV vaccine should be lower than 20 yuan and 50-100 yuan for people who want the vaccine; people who don't want the vaccine choose prize lower than 50.The main way of encouraging people to accept HPV vaccine is health education in hospital,than is the recommendation from nurses or dociors.Conclusion:1.The prevalence of HPV-H in community women is lower than the national rate.2.Sexual life is an important risk factor for HPV-H infection.3. People's knowledge of HPV is poor,low age group has the poorest knowledge and the will of HPV vaccine inoculation,that means the relevant health education in young women in communities is needed.4.The acceptance of HPV vaccine are affected by the following factors:women's knowledge about HPV infections,the cost, safety and effecting of HPV vaccine,the source of recommendation.The key factor for the success of HPV vaccine program is health education,which can improve people's knowledge.