The Clinical Observation Of Treating Chronic Renal Failure By Selecting Drug According To The Thinking Of Identifying The Guijing Properties Of Disease

Objectives:To observe the Clinical observation of treating Chronic Renal Failure by selecting drug according to the hypothesis of Identifying the Guijing Properties of Disease(CRF)and provide clinical proof for Optimizing The composition of prescrPtion through Clinical validation of the thinking.Materials and Methods:sixty patients with chronic renal failure from the kidney internal medicine out-patient of the First Hospital of Wuhan was selected,whose zheng-type was Spleen and Kidney Qi Deficiency-type with wet-type or Blood stasis-type. Treatment group had 28 cases and control group had 32 cases,Both groups were given low-salt,low fat,low-phosphorus and high-quality low-protein diet.According to the condition of patients,the treatment was given such as anti-infection,control of blood pressure,and correcting water,electrolyte and acid-base balance disorders."Shenshuaiyihao"was used to treat the control group, treatment group were treated with a new drugs,Carried out the thinking of"identifying the Guijing properties of disease".Both groups were treated for 8 weeks,and clinical data was collected for two groups before and after treatment.Then,clinical symptom score,serum creatinine(Scr),blood urea nitrogen(BUN), creatinine clearance rate(Ccr),hemoglobin(Hb),total red blood cell(RBC),hematocrit(Hct),calcium(Ca),phosphorus(P)and calcium phosphate product was compared between two groups.After normal distribution and the homogeneity of variance was tested, Data was signed with the mean±standard((?)±s).Measurement data was test by t-test,count data with chi-square test,and level data with Ridit test.Result:1,The comparison of clinical efficacy between Treatment group and control group:There was not significant difference between two groups(P＞0.05),the two groups had no significant results,efficacy of the treatment group is not better than the control group.2,The comparison of Chinese medicine symptom score between Treatment group and control group:Symptom score decreased compared before and after treatment,there was significant difference between two groups(P＜0.05).Compared between the two groups after treatment, There was not significant difference(P＞0.05),which meaned both Two programs can improve the clinical symptoms,but the treatment group was not better than the control group.3,The comparison of Renal function between Treatment group and control group:The Scr of the treatment group was decreased,there was significant difference between two groups(P＜0.05).Compared between the two groups after treatment,There was not significant difference(P＞0.05),which meaned the treatment could improve renal function,but there was not significant difference between two groups.4,The comparison of Hb,RBC and Hct between Treatment group and control group:Both groups can improve the anemia,There are advantages of the treatment group.5,The comparison of calcium and phosphorus metabolism between Treatment group and control group:There was not significant difference between two groups(P＞0.05).Conclusion:1,Selecting drug according to the hypothesis of Identifying the Guijing Properties of Disease could improve the anemia,which is better than the control group。There are not advantage on improving clinical symptoms,Renal function,calcium and phosphorus metabolism.The proof is not enough the treat group is better than the control group on advantage of selecting drug according to the hypothesis of Identifying the Guijing Properties of Disease.2,A further study is necessory to prove the advantages of Selecting drug according to the hypothesis of Identifying the Guijing Properties of Disease.