Epidemiologic Study On The Risk Factor Of Hepatoma

[Objectives]To study the main risk factors and etiological clues of primary hepatic carcinoma in Fujian Province and provide the scientific basis for controlling and preventing hepatic carcinoma[Methods]A case-control design were used for analyses.The 836 subjects of the study were all Fujian residents and had lived in Fujian for over 10 years.The 406 patients from the Hospital of Fujian were newly diagnosed with primary hepatic carcinoma according to the pathologic diagnoses and were able to cooperate with the interviewers. A structured questionnaire was administered face to face to all subjects. The 430 cancer-free controls were randomly recruited from the individuals that visited the same hospitals as the cases which had no history of cancer. A sample of 5ml blood was collected from each participant. EpiData 3.1 was used to collect and SPSS 13.0 for windows to analyze the data. Data were input to the computer by the software of SPSS analyzed with Chi-square test and the conditional Logistic regression.[Results]1. There ware no statistics difference between the two group in the aspect that age, gender, marriage, educational level,family income and living expenses and so on (p>0.05). Multiple logistic regression analysis showed that hepatitis B (OR=43.196), famer(OR=6.407), hepatoma history of first degree relative(OR=5.439), Psychological stress(OR=4.747), touching poisonous or noxious substance(OR=2.412), eating pickled food ( OR = 2.138 ) ,drinking >60l/month(OR=1.490), tobacco smoking amount≥248200 (OR=1.377) were the risk factors of hepatoma cancer; while drinking tea(OR= OR=0.721) , eating fuit(OR=0.744) and strength of task (OR=0.493) were the protective factor of hepatoma. The analysis of interaction showed that hepatitis B appeared multiplicative interaction with psychological stress, eating pickled food. 2. GenderMale: Multivariate conditional logistic regression analysis showed that famer(OR=8.912), touching poisonous or noxious substance(OR=2.727), smoking amount(OR=1.782), drinking>60l/month(OR=1.689) , eating pork (OR=1.813), eating pickled food(OR=2.092), hepatoma history of first degree relative(OR=4.899), hepatitis B(OR=47.785), Psychological stress(OR=3.845) were the risk factors of hepatoma cancer; while drinking tea(OR= 0.738) , eating vegetables(OR=0.567) and strength of task(OR=0.462) were the protective factor of hepatoma. The analysis of interaction showed that hepatitis B appeared multiplicative interaction with Psychological stress, eating pickled food, , drinking>60l/month. Female Multiple conditional logistic regression analysis showed that eating pickled food(OR=16.431), hepatoma history of first degree relative(OR=8.572), hepatitis B(OR=23.819), Psychological stress(OR=60.126) were the risk factors of hepatoma cancer; while eating roughage (OR= 0.363) were the protective factor of hepatoma.3. Age group<50: Multiple conditional logistic regression analysis showed that eating pickled food(OR=1.979), hepatoma history of first degree relative(OR=6.976), hepatitis B(OR=118.763), Psychological stress(OR=5.809) and A-type temperament (OR=2.127)were the risk factors of hepatoma cancer.≥50: Multiple conditional logistic regression analysis showed that drinking>60l/month(OR=2.121) , eating pork (OR=1.895), hepatoma history of first degree relative(OR=5.229), hepatitis B(OR=35.414), Psychological stress(OR=3.765) were the risk factors of hepatoma cancer; while drinking tea(OR= 0.698) , eating vegetables(OR=0.545) were the protective factor of hepatoma. The analysis of interaction showed that hepatitis B appeared multiplicative interaction with psychological stress, worried.[Conclusions]1. hepatitis B(OR=43.196), farmer(OR=6.407), hepatoma history of first degree relative(OR=5.439),Psychological stress(OR=4.747), touching poisonous or noxious substance(OR=2.412), eating pickled food(OR=2.138), drinking drinking>60l/month(OR=1.490), tobacco smoking amount≥248200(OR=1.377)were the risk factors of hepatoma cancer; drinking eat (OR=0.721), eating fuit(OR=0.744), the strength of task (OR=0.493) were the protective factors of hepatoma cancer.2. The risk factors of hepatoma cancer are different at different gender and different age period. Therefore, to carry out our work on the prevention of liver cancer, we should not only address their risk factors, but also consider the characteristics of population at different gender and different age period.