Study On The Relationship Between Interleukin-10 Gene Polymorphisms And Cerebral Infarction

Object To investigate whether three diallelic polymorphisms at the position - 1082,- 819 and - 592 in the promoter region of the IL-10 gene were associated with cerebral infarction(CI).Methods The IL-10 gene - 1082, - 819 and - 592 position polymorphisms were genotyped by amplification refractory mutation systems-polymerase chain reaction (ARMS-PCR) methods in 181 patients with cerebral infarction(CI group) and 115 healthy subjects (control group). Results There was statistical significance in the distribution frequency of IL-10-1082G/A allele in the CI group as compared with the control group (χ~2 = 6.643 ,P=0.010).The IL-10-1082 A allele frequency was 92.3%,and the control group was 86.1%;there was statistical significance between the two groups(P=0.015).There were no statistical significance in genotype distribution frequency of IL-10-592C/A and -819C/T and allele frequency as compared with the control group (P>0.05).Conclusion IL-10-1082G/A gene polymorphisms have been involved in CI,in which the increased A allele frequency is associated with the occurrence of CI.