The Analysis Of Augumentation Index And Its Relative Factors

AIM: Central artery pressure is the blood pressure at aortic root. For different structure of peripheral arteries, central artery pressure indicates the real blood vessels functions better than the pressure at other arteries. The augmentation index (AI) indicates the flexibility of the whole aortic system, and also sensitively presents the status of pressure wave reflex caused by the changes of large artery and arterioles. The aim of this study is to observe augumentation index in different populations and its relative factors.Methods: One town community and three village communities of Da Xing District in Beijing were randomly selected in 2007. 0'blood glucose (BG),OGTT₁20'BG,total cholesterol (TC),triglyceride (TG),systolic blood pressure (SBP),diastolic blood pressure (DBP) and AI were examined in 2110 persons (18 to 82 years old) . Based on the blood lipid, blood glucose and blood pressure, all subjects were divided into healthy, diabetes, hypertension, dislipidemia groups, and redivided into 15 subgroups. Four kinds of statistical analysis were used as follow: 1. Principle of statistic discriptions of all data in each group; 2. Square's analysis of AI between different groups and between different subgroups; 3. T-test of AI in both gender in different groups; 4. Multielement gradual regressive analysis of the AI and its relevant variances in healthy group, diabetes group, hypertension group and dislipidemia group.Results:I. Comparion of AI in different groups and their subgroups1. The AI of healthy group is lower than that in whole patient (77.27±13.380 vs 81.64±12.886; P<0.05), at the same time AI in healthy group is lower than that separately in diabetes, hypertension and dislipidemia groups. AI of hypertension group is the highest among four groups. The AI of each group are 77.27±13.380, 80.40±12.989, 83.23±12.809, 80.97±12.865 (P<0.05).2. There are significant differences of AI in hypertension subgroups(P<0.05). The AI of each group respectively are 84.65±12.198 of pure hypertension group, 81.88±12.976 of hypertension with diabetes group, 83.63±12.976 of hypertension with dislipidemia group and 81.3±13.204 of hypertension with diabetes and dislipidemia group.3. The significant differences of AI also exists among subgroups in dislipidemia patient(P<0.05). The AI of pure hypertriglyceride group is 78.12±12.641, of pure hypercholesterolemia group is 82.05±12.560 , of hypertriglyceride with hypertension group is 83.54±13.147, of hypertriglyceride with diabetes group is 79.65±10.277, of hypertriglyceride with hypertension and diabetes group is 81.35±13.481, of hypercholesterolemia with hypertension group is 83.78±11.621, of hypercholesterolemia with diabetes group is 74±16.799, of hypercholesterolemia with hypertension and diabetes group is 80.42±13.257, and of pure hyperlipemia is 79.73±12.715. 4. Differences of AI between all of patients with one main metabolism elements and healthy group were significant(P<0.05). The mean AI respectively in healthy group is 77.27±13.380, in diabetes group 79.71±12.932 ,in hypertension grou 84.65±12.198 and in hyperlipemia group 79.73±12.715.5. The mean AIs of both genders in healthy, diabetes, hypertension and dislipidemia groups have significantly differences (P<0.05). The AI of the healthy group are: female 79.85±12.113, male 72.14±14.333;of the diabetes group are: female 81.19±12.257,male 77.13±13.861;of hypertension group are:female 87.3±11.073 , male 80.89±12.762 ; of hyperlipemia are : female 83.23±11.568,male 74.56±12.623. The AI of female is higher than that of male.II. The multielement gradual regressive analysis of the AI and its relative factors in each group1. Multielement gradual regressive analysis shows that in healthy group AI is correlative with 0'BG (typical coefficient = 0.065),TC (typical coefficient = 0.09),age (typical coefficient = 0.029) (P=0.000). There is significant difference of AI based on ages (P<0.05). The AI is 68.38±14.29 of age from 18 to 30, is 77.16±11.61 of age from 31 to 40, is 80.02±12.91 of age from 41 to 50, is 82.97±12.98 of age from 21 to 60 and is 84.14±12.038 of age elder than 60. AI is gradually increasing with age.2. AI is correlated with SBP(typical coefficient = 0.123) and 120'BG (typical coefficient = -0.125) (P=0.000) in hypertension group, is correlated with DBP (typical coefficient = 0.215) and 120'BG (typical coefficient = -0.128) (P=0.000) in dislipidemia group, while AI has no correlative factors in diabetes group. Conclusion:The AIs of patients with diabetes, hypertension and dislipidemia which are main elements of metabolism syndrome are significantly higher than that in healthy group, among them patients with hypertension has highest AI; and AI of female is higher than that of male in all groups; at the same time. AI has relativity with 0'BG, TC, age, SBP and DBP, while the relativity with 0'BG and TC is weak.