The Effect Of Remote Limb Ischemic Conditioning On Human Central Aortic Pressure

Objective: Ischemic cerebrovascular disease is the main reason of thesevere acute severe case with high morbidity and high mortality rate. Theprotection treatment measures from badic research into clinical is relativelydeficiency. There are a large number of studies which have shown that theremote ischemic preconditioning and ischemic postconditioning throughlimb repeatedly ischemia reperfusion can have protective effect on focalcerebral ischemia and global cerebral ischemia. This intervention means iseasy to use, and has broad prospects for clinical use, but the clinical securityof this intervention need to be further confirmed. The main purpose of thispaper is to investigate the effect of remote limb ischemic conditioning（RLIC）byrepeatinglimb ischemia-reperfusiononcentralaorticpressure.Methods: Healthy volunteers were randomly selected and wereperformed remote limb ischemic conditioning (RLIC)(intermittent armischaemia through five cycles of5min inflation and5min deflation of ablood-pressure cuf). Central aortic diastolic pressure, systolic pressure,augmentation pressure and augmentation index were measured at various time point (before RLIC, during ischemia, during reperfusion and30minutes after the operation.Results: Repetitive limb ischemia reduced central aortic diastolicpressure and systolic pressure, but the augmentation pressure andaugmentation index at each time point were not affected.Conclusion: Remote limb ischemic conditioning by repeating limbischemia-reperfusion is not detrimental to central aortic pressure and is asafe and easy treatment measure.