The Clinical Application Of Non-invasive Center Artery Pressure Measurement In Hypertension Treatment

Objective:To study the relationship between noninvasive and invasive central aortic pressure. Also to explore the clinical application of non-invasive center aortic pressure measurement in hypertension treatment.Methods:One hundreds forty patients including 79 male and 61 female, the age of years (57.51±15.18), were recruited for this study. The data of invasive central aortic pressure (CSP) and non-invasive central aortic pressure (NCSP) by HEM9000AI in 50 patients were collected. And other 90 patients were randomly divided into ACEI,CCB and Beta-blockers groups. The peripheral arterial blood pressure(SBP),NCSP and Argumentation Index(AI) were measured before and after medication in two weeks by HEM9000AI. The data were analyzed by paired t-test,independent t-test and simple correlation.Results:1. The correlation between noninvasive and invasive central aortic pressure:The patients group:There was high correlation between NCSP(140.84±13.77mmHg) and CSP (142.36±19.04mmHg) r=0.972 (p<0.01), no statistical difference was found between the data of them (p>0.05). There was high correlation between SBP (131.44±17.24mmHg) and CSP (142.36±19.04mmHg) (r=0.900, p<0.01), but there was significant difference between the data (p<0.01). The high correlation (r=0.751, p<0.01) was found between CSP (142.36±19.04mmHg) and AI r=0.751(p<0.05).The control group:There was high correlation between NCSP(110.71±15.46mmHg) and CSP (114.57±12.62mmHg) r=0.920 (p<0.01), but no statistical difference was found between the data of them (p>0.05). The correlation between SBP(122.57±14.95mmHg)and NCSP was high r=0.694 (p<0.05), the difference also was significant between them (p<0.01). And the high correlation (r=0.683, p<0.05)was found between CSP (114.57±12.62mmHg) and AI (59.18±15.87%) Use the normal group's mean of SBP, NCSP, CSP as reference to standardize the difference value between SBP, NCSP, CSP of the two groups. The standardization rate are (7.3±1.8)%(SBP), (21.7±5.4)%(NCSP), (24.3±5.6)%, (CSP). The difference between the first two was significant (p<0.01). And no statistical difference was found between the latter two(p>0.05).2. The response of peripheral arterial blood pressure and central aortic pressure to different antihypertensive drugs:There are significant difference between the SBP,NCSP before and after medication of ACEI,CCB and Beta-Blockers, respectively (p<0.05). Setting SBP as reference standard to analyze NCSP, there was no statistical difference between ACEI and CCB(p>0.05), but the difference between ACEI and Beta-Blockers was significant (p<0.05)3. The AI's responsive to different antihypertensive drug.There are significant difference between the AI of ACEI,CCB and Beta-Blockers, respectively (p<0.05),and no statistical difference among ACEI,CCB and Beta-Blockers groups (p>0.05)Conclusion:1. There is correlation between noninvasive and invasive central artery pressure. But there is no statistical difference for the data between the two. So that, non-invasive central aortic blood pressure can replace invasive of central aortic for evaluation central aortic blood pressure.2. There are significant antihypertensive effects of ACEI, CCB andβ-receptor blockers on peripheral arterial pressure, central aortic blood pressure. But there are better antihypertensive effects of ACEI, CCB thanβ-receptor blockers on central aortic blood pressure. So non-invasive arterial blood pressure is better index than the peripheral arterial blood pressure.3. There are significantly increased for the value of center of arterial blood pressure and AI in the patients group of cardiovascular disease. Also there is positive relationship between the two index.