| Objective:By clinical observation study respiratory tract infection on the effects of myocardial enzymes, to know whether the degree of myocardial injury is different when the degree of respiratory tract infection is different, and the clinical significance of the myocardial enzymes, Guide the application of drugs which benefit myocardium.Methods:Children who sufferred from respiratory tract infection were treated at the second hospital of Hebei Medical University From December 2007 to January 2009 and 20 normal children were collected as research subjects, among of all, 30 patients with respiratory tract infection, 100 patients with pneumonia, 40 patients with heart failure due to pneumonia. We collect the venous blood of fasted patients in early morning, and assay myocardium enzyme in Japan's Hitachi 7600-020 automatic analyzer. The data is analyzed in statistic software of SPSS 13.0,the results are expressed by mean±standard deviation( x±s). The data between every two groups is analyzed in Student-Newman-Keuls(q-test) , the data abnormal rate of myocardial enzyme among the four groups is analyzed in X2, and P<0.05 is regarded as having statistical significance.Results:1. In the control group, the upper respiratory tract infection group, the pneumonia group, the heart failure due to pneumonia group, the values of CK is 73.00±36.90 U/L, 73.73±42.42 U/L, 98.06±112.32 U/L, 93.28±59.06 U/L. Comparison among the four groups, the results show that P>0.05, there are no statistical significance.2. In the control group, the upper respiratory tract infection group, the pneumonia group, the heart failure due to pneumonia group, the values of CK-MB is 19.25±8.99 U/L, 20.63±9.04 U/L, 25.46±15.16 U/L, 34.35±22.88 U/L. The results of the mutual comparison among the four groups show that P< 0.01 between the control group and the heart failure due to pneumonia group ,between the upper respiratory tract infection and heart failure due to pneumonia group and between the pneumonia group and heart failure due to pneumonia group, there are statistical significance; but there are no statistical significance among the control group ,the upper respiratory tract infection group and the pneumonia group (P>0.05).3. In the control group, the upper respiratory tract infection group, the pneumonia group, the heart failure due to pneumonia group, the values of LDH is 182.95±55.22 U/L, 253.30±66.24 U/L, 336.49±100.09 U/L, 398.05±106.75 U/L. Comparison of LDH among the four groups, the results show that there are statistical significance among the four groups(P<0.05). 4. In the control group, the upper respiratory tract infection group, the pneumonia group, the heart failure due to pneumonia group, the values of CK is HBDH is 174.95±57.35 U/L, 215.83±58.04 U/L, 272.63±95.32 U/L, 327.93±124.73 U/L. Comparison of HBDH between the control group and the pneumonia group , between the control group and the heart failure due to the pneumonia group, between the upper respiratory tract infection and the pneumonia group, between the upper respiratory tract infection and heart failure due to pneumonia group, between the pneumonia group and heart failure due to pneumonia group, the results show that there are statistical significance (P<0.01). But there are no statistical significance between the control group and the upper respiratory tract infection group. (P>0.05)5. The positive rate of myocardial enzyme are as follows: in the control group, the positive rate of CK is 0%, the positive rate of CK-MB is 20%, the positive rate of LDH is 25%, the positive rate of HBDH is 20%; in the upper respiratory tract infection group, the positive rate of CK is 0%, the positive rate of CK-MB is 23.3%, the positive rate of LDH is 43.3%, the positive rate of HBDH is 26.7%; in pneumonia group, the positive rate of CK is 11%, the positive rate of CK-MB is 42%, the positive rate of LDH is 95%, the positive rate of HBDH is 54%; in the heart failure due to pneumonia group, the positive rate of CK is 10%, the positive rate of CK-MB is 67.5%, the positive rate of LDH is 100%, the positive rate of HBDH is 82.5%. The results show: Comparison of the positive rate of each indicator in the same group, the results are same (LDH>HBDH≥CK-MB>CK). The sensitivity of LDH is highest, CK is minimum; The positive rate of myocardial enzyme will gradually increase when the disease is worsening. Comparison of the positive rate of CK-MB, LDH, HBDH among the four groups, the results show that there are statistical significance (P<0.01). But there are no statistical significance about the positive rate of CK among the four groups.6. In pneumonia group ,we analyse the scatterplot and the trend line about myocardial enzyme and age. The result is that the values of CK and CK-MB are decreased and gradually closing to the normal when the age increases. The value of CK-MB is decreased even more apparent than CK. But the values of LDH and HBDH are not change with age. Conclusion: 1. Myocardial enzymes will become abnormal when the children suffer from respiratory tract infection. 2. Each of the indicator in myocardial enzyme has different rule to change, thereinto, LDH and HBDH are most vulnerable. 3. The more serious the degree of respiratory tract infections is, the more obvious myocardial enzymes become high.
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