| Objective:25-hydroxy vitamin D（25-（OH）D）was detected and analyzed in hospitalized children with respiratory tract infection in Shiyan area,to understand the differences of25-（OH）D levels and distribution in different genders,ages,seasons and diseases.To provide reference for the prevention of respiratory tract infection in Shiyan area.Methods:From November 2020 to October 2021,285 children aged 0-7 who were hospitalized for respiratory tract infection in Shiyan People’s Hospital were selected as the experimental group,and 131 healthy children who underwent physical examination in our hospital during the same period were selected as the control group.25-（OH）D was measured in all enrolled children.Basic information（name,sex,age,native place,current address）,time of admission and clinical diagnosis were collected.The distribution of 25-（OH）D was divided into normal: ≥30ng/m L（75nmol/L）,deficient: <30ng/m L（75nmol/L）;Deficiency was further divided into subclinical deficiency: ≥20ng/m L（50nmol/L）and severe deficiency: <20ng/m L（50nmol/L）.The 25-（OH）D levels of children with respiratory tract infection and healthy children were compared,and the 25-（OH）D levels of children with respiratory tract infection were compared in different genders,different ages,different seasons and different diseases.Results:1.There was no significant difference in the average level of 25-（OH）D between the respiratory tract infection group and the health examination group（P>0.05）.The distribution of 25-（OH）D in the two groups was significantly higher in the respiratory tract infection group 40 cases（27.97%）than in the health examination group(5 cases（7.14%）,and the difference was statistically significant（P<0.05）.2.There was no significant difference in the average level and distribution of 25-（OH）D among groups by sex and age（P>0.05）.The average level of 25-（OH）D was38.48±13.18 ng/m L in autumn and 24.21±10.90 ng/m L in winter,37.40±12.21 ng/m L in summer and 38.48±13.18 ng/m L in autumn,and significantly lower in winter and spring than in summer and autumn.The difference was statistically significant（P<0.05）.The distribution of 25-（OH）D in winter + spring and summer + autumn was compared,99cases（71.74%）of 25-（OH）D deficiency in winter + spring was higher than 44 cases（29.93%）in summer + autumn,the difference was statistically significant（P<0.05）.39cases（39.39%）of severe deficiency in winter and spring were higher than 1 case（2.27%）in summer and autumn,with statistical significance（P<0.05）.3.Respiratory tract infection was divided into upper respiratory tract infection and lower respiratory tract infection.There was no significant difference in the average level and distribution of 25-（OH）D between the two groups（P>0.05）.The average level of 25-（OH）D was 32.43±13.32 ng/m L for mild pneumonia,which was higher than 25.97±14.60ng/m L for severe pneumonia.The difference between the two groups was statistically significant（P<0.05）.The distribution of 25-（OH）D between the two groups was significantly higher in severe pneumonia deficiency 18 cases（72.00%）than in mild pneumonia 92 cases（49.73%）,the difference was statistically significant（P<0.05）,and severe pneumonia deficiency 9 cases（50%）was significantly higher than mild pneumonia 23 cases（25%）,the difference was statistically significant（P<0.05）.Pneumonia cases were divided into asthmatic pneumonia and non-asthmatic pneumonia according to wheezing symptoms.The average level of 25-（OH）D asthmatic pneumonia was 30.29±13.22 ng/m L.Non-asthmatic pneumonia: 32.77±13.86 ng/m L.There was no significant difference between the two groups（P>0.05）.The distribution of 25-（OH）D in asthmatic pneumonia was significantly higher in 20 cases（38.46%）than in 12 cases（20.68%）in non-asthmatic pneumonia（P<0.05）.Conclusion:1.Children with respiratory tract infection were more likely to have severe 25（OH）D deficiency than healthy children.2.Vitamin D deficiency was greatly affected by season,and vitamin D deficiency was easy to occur in winter and spring in Shiyan.3.In children with pneumonia,severe pneumonia and asthmatic pneumonia at 25（0H）D were more likely to be deficient or severely deficient.Vitamin D deficiency should be corrected in children with respiratory tract infection,especially in children with severe and asthmatic pneumonia.Meanwhile,it is suggested to develop vitamin D supplement programs in accordance with the seasonal distribution differences of vitamin D levels in different regions. |
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