The Study Of The Relationship Between Osteoporotic Intertrochanteric Fracture Patients' Bone Mineral Density And Bone Metabolism

Objective Discuss the intrinsic link between bone mineral density and bone metabolism in osteoporotic intertrochanteric fracture patients,to provide objective clinical basis for clinical prevention and monitor the treatment of osteoporotic intertrochanteric fracture;to provide more extensive intervention ideas for Chinese medicine;and to provide a theoretical basis for develop a reasonable program of Chinese medicine treatment and prevent disease.Methods In this study we chose 60 cases of patients who to see a docter for the osteoporotic intertrochanteric fracture in Guangzhou University of Traditional Chinese Medicine affiliated orthopedics hospital during February 2008 to February 2009.Reference to《The reference of Chinese medicine Deficiency Syndrome》and《The criteria blood stasis syndrome diagnostic》,as well as editor-in-chief Liu Qingsi《in traditional Chinese and western medicine diagnosis and treatment of osteoporosis》.Which subjects carried out 60 cases of TCM Syndrome Types; Measure the bone mineral density ofuninjured hip(BMD);Measure the bone metabolic targets(TRACP,B-ALP,PTH,CT) of the Serum.Collect these Clinical datas,and then statistical analysis these relevant data with SPSS13.0 version of the application package.Discuss the dependablity between bone mineral density and bone metabolism in osteoporotic intertrochanteric fracture patients. Results In these 60 cases patients who have osteoporotic intertrochanteric fracture,BMD and tartrate-resistant acid phosphatase(TRACP) was negatively correlated,p＜0.01,have statistical significance;BMD and bone alkaline phosphatase(BALP) was negatively correlated,P＜0.01,have statistical significance;BMD and parathyroid hormone(PTH) was negatively correlated,P＜0.01,have statistical significance;BMD and calcitonin have no significant correlation,P＞0.01,have no statistical significance.Linear Regression Analysis of multi-factor regression results suggest that:In this three indicators who have significant of the relevance,BMD and tartrate-resistant acid phosphatase(TRACP) have the best dependablity.Further analysis the dependablity of BMD and tartrate-resistant acid phosphatase in the four TCM syndromes,we found the deficiency of kidney-YANG type have the best dependablity between BMD and TRACP,and then is the asdthenic splenonephro-yang type,and then is the stagnation of vital energy and blood stasis type,and then is the hepatic and renal yin deficiency type.Conclusion According to the investigation and research results,we discovered that the bone mineral density and bone metabolic targets(TRACP, B-ALP,PTH) of the osteoporotic intertrochanteric fracture patients was negatively correlated,TRACP,BALP,PTH values increased with the reduction in BMD;Among the total,BMD and tartrate-resistant acid phosphatase(TRACP) have the best dependablity.In the four TCM syndromes,we found the deficiency of kidney-YANG type who's BMD and TRACP have the best dependablity.