| Diabetic microangiopathy , serious impact on quality of life in patients with diabetes, is the most common and most serious chronic complications of diabetes mellitus .It is also the main cause of death and disabled of diabetes mellitus. diabetic microangiopathy includes diabetic retinopathy(DR) ,diabetic nephropathy (DN) and Diabetic Neuropathy (DNP), which is characterized by tumor microvessel formation, microcirculation and microvascular basement membrane thickening。Diabetic eye complications are one of the major disease which leads to be blind, the risk of blindness of diabetic patients is 25 times than the general population in the United States. 12% Blindness patients (about 8 000persons / year) are caused by diabetes evry year. Diabetic retinopathy is the main causes of blindness. Diabetic nephropathy has become the most common disease that cause the end-stage renal disease in the United States and Europe accounting for40% of all patients with end-stage renal disease. Dialysis patients because of end-stage diabetic nephropathy accounted for 30 % -40 % of alldialysis patients in our country Therefore, the early detection and early intervention in diabetic microangiopathy is particularly important. This paper aims to explore the relationship between the change of platelet parameters and zinc and diabetic microangiopathy, in order to provide the basis for early intervention of diabetic microangiopathy.Materials and Methods: According to diabetic diagnostic criteria and typing standard of WHO1999,we selected 110 cases of inpatients who were clearly diagnosed with diabetes mellitus(DM)from March 2008 to March 2009 in our hospital endocrinology department. which has no acute infection, no cardiac insufficiency,respiratory failure,liver dysfunction and cerebral vascular accident, non-malignant tumor and thrombotic diseases , they were divided into two groups , one with microvascular disease(A group) , the other without (B group)。A group has 60 cases (32 males and 28 females),aged 32-72, with an average ageof(49 +13). B group has 50 cases(22 males and 28 females), aged 31-73, with an average age of ( 50 +12). The control group includes 60 normal cases(29 males and 31 females), aged 29 - 69 years old, with an average age of (47±13).the control group with normal blood pressure, fasting blood glucose(FBG), blood lipids, without heart,brain,liver,kidney and lung disorders and other thrombotic diseases.All the subjects were reviewed the history and physical examination in detail.Blood pressure(systolic and diastolic blood pressure)and weight were tested and recorded by one person. We measured fasting glucose (FBG), glycosylated hemoglobin (HbA1c) , zinc (Zn) concentration , platelet parameters (MPV, PDW, PLT)with 8 hours or more fasting elbow venous blood. Collected 24-hour urine, record the volume, took 10 milliliters from the mixing urine then sent to be measured the urinary albuimin. Semmes-weinstein monofilament inspection, sensory testing of vibration, temperature checks are carried out by one person.The diagnostic criteria for Diabetic microangiopathy:①DR in accordance with the 1985 Third National Conference on ophthalmic diagnostic criteria[2], fundus fluorescein angiography or vascular confirmed ophthalmoscope:②DN24-hour urinary albumin≥300 mg. (To exclude urinary tract infection, glomerulonephritis, etc.)③peripheral neuropathy long wire means 10 Hackney (Semmes-weinstein monofilament) inspection, sensory testing of vibration, temperature checks for more than three inspections, and one has a more than abnormal scheme group of diabetic peripheral neuropathy. All data used mean±standard deviation (x + s), and inter-group used t test. The relationship between MPV and FBG, HbA1C, PDW used linear correlation analysis.The results: diabetic microangiopathy group (A group) comparing with nonmicrovascular disease group (B group) diabetes type, gender, age are not significant (P> 0.05), but weight, duration, systolic blood pressure are statistically Significancet (P <0.05 or P <0.01). Diabetic group (A + B) comparing with normal control group ,MPV,PDW,FBG,HbA1C are also increasing statistically significant (P <0.05 or P <0.01), PLT has no significant change (P> 0.05). And diabetic microangiopathy group (A group) comparing with diabetes non microvascular disease group (B) ,MPV,PDW,FBG,HbA1C have statistical significance, the difference has statistical significance. Diabetic group (A + B) compared with normal control group , The decrease of Zn has statistically significant difference (P <0.01), diabetic microangiopathy group (A group) comparing with nonmicrovascular disease group (B group) The reduction of Zn has statistically significant difference (P <0.01). The relationship between MPV and FBG, HbA1C, PDW exists positive correlation (0 |
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