The New Target System Of Epidemiological Screening For Abdominal Abesity

Metabolic syndrome(MS) is main connotation of diabetes mellitus or impaired glucose regulation,hypertension,lipid abnormality,central obesity, Pathological basis of insulin resistance(IR) and clinical characteristics is Clinical syndrome metabolic disease and effect of human health.MS has a high incidence in the world,has become hot spot of endocrine,cardiovascular and basic medicine for it's close connection with Cardiovascular Disease and tetrad segregation 2-type.MS is a syndrome with several faction origin and complex dysfunction,It's pathogenesis is still unclear,in present study,MS was a result of multivariate interaction and has relationship with many factors such as inheritance,immune,environment and so on.Insulin resistance(IR) is considered to be the central link and the origin of a disease,Different manifestation of MS always goes with significant IR.IR is core position on the process of occurrence and development of MS.Sustainable development of IR results in the formation of MS.It will develop into cardiovascular disease,Ⅱ-diabetes mellitus with the gathering several cardiovascular risk factors related.But the clinical presentation of MS is various,IR is not the unique causation because the element of MS is charged by independent factors of IR.Present observe believe that pathogenesis of MS is mainly about IR gathered adipose factor,inflammatory mediators,FFA interaction become MS in present observation based on adiposity,susceptible factors of Genetic is internal cause of MS,environmental factors promote development MS.large-scale investigation found,abdominal obesity and MS and direct related,it may is initial factor,and other related.Present research shows that:visceral fat is special fat it has endocrine function,biological characteristics different from subcutaneous adipose tissue.visceral fat secretion more fat factor,adjust human function,effect sensitive pressure endothelial fibrinolysis activities inflammation of insulin and main path physiological process.Reproductive endocrine dysfunction of fat is IR important reasons of visceral obesity.Test monitoring of visceral obesity for prevention diagnose diseases important effect.Survey found obese patients and a visceral fat accumulation patient is increased sickness factor.1999 yeas of WHO job 2002 yeas NCEP-ATPⅢa new defined metabolic syndrome NCEP-ATPⅢand WHO proposed MS diagnostic index,EGIR and AACE also definition.NCEP-ATPⅢdiagnostic index for epidemiology survey, application widely.2004 year diabetes mellitus of Chinese medical association making diagnostic index of Chinese.Recently the results show that visceral secretion cell in MS in the results show that has effect of important.Early warning Obesity diagnostic of MS.2005 year 4 months IDF can definition and published.2007 year Chinese lipid abnormality of Compass is MS different populations.MS incidence of cardiovascular diseases was highest.Reason no early warning indexes of scientific simple accurate,at present at present method use main of visceral obesity indexes,limitation see:①BMI:this indexes is international diagnostic MS one,it calculation method BMI= body mass/mass height2,with body mass and mass height,and visceral obesity unrelated,and it has limitation.This indexes different sex body mass height,individual difference significantly,indexes deficiency.WC/hip line,WHR was lack diagnostic index different populations,very Difficult using in epidemiology.Visceral obesity pathological significance before are three indexes and it have defect of specific and accuracy.Early identification MS patients and time treatment,prevent target organ damage.Life style of change is important measure OF MS,drug therapy is also prevent atherosclerosis improve life quality prolong life.In this study is science a feasibility,form abdominal obesity distribution of and find screening method at abdominal obesity.Research methods:Used more layers randomly sample Investigation method,comprehensive consideration regional economy culture other conditions, inclusion every living level,Cultural level,18 age above 3335 human in Changchun Jilin.Designed related questionnaire including:age,sex,past medical history,history of genetic diseases,taking drugs and so on.According to diagnostic criteria of lipid abnormality of Chinese adult on 2007,We checked the blood biochemistry and the basic parameters by all person in the survey.It has been divided into MS patient group,middle group and normal group in the result.Compared with statistical difference of three indexes of three group persons by waist circumference(WC)/ height WC/(upper limb + calf circumference) waist longitudinal sine/waist transverse diameter.Results:waist circumference(WC)/ height WC/(upper limb + calf circumference) waist longitudinal sine/ waist transverse diameter that three indexes compared with control group have significant difference(P＜0.001 ).three indexes of intermediary group and normal control group have significant difference(P＜0.001).Conclusion:In this study of three indexes can screening and diagnosis, guiding next diagnosis and treatment,this methods is scientific,rapid,simple,economy,but In this study field of investigation limited to about Changchun group,should further of investigation in national scale,production standard suitable for China.