Prospective Study Of Development And Recovery Of Abdominal Obesity And Metabolic Syndrome

Objective:To explore the significance of abdominal obesity in the development and recovery of metabolic syndrome.Methods:This study conducted a cross-sectional survey of metabolic syndrome in 646residents of Shenyang community in 2010.The visceral fat area was measured by MRI,and the group comparison was performed with 80cm~2as the cut point.Through the determination of blood lipids,75g glucose tolerance test,blood pressure,abdominal circumference index,metabolic syndrome was identified in accordance with the International Diabetes Federation criteria.After 1.5 years of follow-up,we re-test the above indicators to determine the outcome of the metabolic syndrome and non-metabolic syndrome population.Results:1.The prevalence of metabolic syndrome in Shenyang in 2010 was 35.14%.Among them,male prevalence rate was 46.39%,female prevalence rate was 24.16%,male prevalence rate was significantly higher than female prevalence(P<0.05);VFA≥80cm~2group,the prevalence of metabolic syndrome was 55.48%,VFA<80cm~2group,the prevalence of metabolic syndrome was 18.36%.The prevalence of metabolic syndrome in VFA≥80cm~2group was significantly higher than that in VFA<80cm~2group(P<0.05).2.In each component of metabolic syndrome(central obesity,abnormal blood glucose,abnormal blood pressure,hypertriglyceridemia,and low-density lipoprotein cholesterol),the prevalence of central obesity was the highest(45.51%).VFA≥80cm~2group,the prevalence of central obesity was the highest(72.95%).The prevalence of hypertriglyceridemia,abnormal blood pressure,abnormal blood glucose and low-density lipoprotein cholesterol were 60.96%,58.56%50.34%,22.60%.VFA<80cm~2group,the prevalence of abnormal blood glucose was 34.75%,hypertriglyceridemia,abnormal blood pressure,central obesity,low-density lipoprotein cholesterol was respectively31.64%,29.66%,22.88%,17.23%.The prevalence of abnormal blood glucose,abnormal blood pressure,hypertriglyceridemia,central obesity in patients with VFA≥80cm~2were significantly higher than those in patients with VFA<80cm~2(P<0.05).3.Metabolic syndrome components aggregation:VFA≥80cm~2group,0,1,2,3,4,5kinds of abnormal components accounted for 4.1%,11.6%,28.8%,30.8%,19.5%and 5.1%;VFA<80cm~2group,0,1,2,3,4,5 kinds of abnormal components accounted for 29.7%,28.0%,24.0%,13.8%,4.0%,0.6%.Compared with VFA<80cm~2group,the number of metabolic syndrome in VFA≥80cm~2group gathered more,the difference was statistically significant(P<0.05).4.In the non-metabolic syndrome population,the ratio of male,waist circumference,hip circumference,body weight,BMI,WHR,visceral fat area,subcutaneous fat area,systolic blood pressure,diastolic blood pressure,2-h plasma glucose,TG,LDL-C,UA,serum creatinine,current smoking rate and drinking rate in VFA≥80cm~2were significantly higher than VFA<80cm~2group(P<0.05),while HDL-C was significantly lower than VFA<80cm~2group(P<0.05).5.Among the patients with metabolic syndrome,the ratio of male,waist circumference,hip circumference,body weight,BMI,WHR,visceral fat area,UA,and serum creatinine in VFA≥80cm~2group were significantly higher than those in VFA<80cm~2group,while HDL-C was significantly lower than the VFA<80cm~2group(P<0.05).6.Among the 646 cases included in follow-up,443 cases were followed up for 1.5 years,with a follow-up rate of 68.58%.During the first visit,419 non-metabolic syndromes were screened out,280 of them were followed up with a follow-up rate of 66.83%.Metabolic syndrome occurred in 25.71%(72/280)of these non-metabolic syndrome patients after 1.5 years of follow-up.In VFA≥80cm~2group metabolic syndrome is47.83%(44/92),in VFA<80cm~2group metabolic syndrome is 14.89%(28/188).The proportion of metabolic syndrome in non-metabolic syndrome patients with VFA≥80cm~2was significantly higher than that in VFA<80cm~2group(P<0.05).During the first visit,227 patients with metabolic syndrome were screened out,163 of them were followed up,with a follow-up rate of 71.81%.After 1.5 years of follow-up,26.38%(43/163)of these metabolic syndrome patients were classified as non-metabolic syndrome.Among them,VFA≥80cm~2group,18.80%(22/117)were classified as non-metabolic syndrome,VFA<80cm~2group,45.65%(21/46)were classified as non-metabolic syndrome.The proportion of metabolic syndrome patients recover to non-metabolic syndrome in VFA≥80cm~2group was significantly lower than that with VFA<80cm~2group(P<0.05).Conclusion:1.The prevalence of metabolic syndrome in VFA≥80cm~2group was significantly higher than that in VFA<80cm~2group,and the number of metabolic syndrome in VFA≥80cm~2group gathered more.2.In the abdominal obesity group without metabolic syndrome at baseline,after 1.5years of follow-up,the proportion of metabolic syndrome was significantly higher than that of non-abdominal obesity group;In the abdominal obesity group with metabolic syndrome at baseline,after 1.5 years of follow-up,the proportion of non-metabolic syndrome was significantly lower than that of non-abdominal obesity group3.Abdominal obesity is a risk factor for the development of metabolic syndrome now and in the future.