| Objeetive: To evaluate the effect and significance of mild hypothermia on the intracranial pressure, oxygen saturation, bloodgas analysis and Electrolyte of patients with severe head injury.Method: A total of 40 patients with severe brain injury (3≤GCS≤8 on admission) were randomly divided into the hypothermia therapy group (n=19) and the control group (n=21). The intracranial pressure were measured by lumbar puncture dynamically. Pulse oxygen saturation (SpO2) was monitored by uninvassived monitor and blood sampler from thigh arterial at the same time were analyzed. The oxygen saturation, blood gas analysis and Electrolyte were measured dynamically.And the relationship between the change of the indexes and the prognosis in the 2 groups was also studied.Results: After 24 hours of hypothermic treatment, the ICP decreased gradually (P<0.05). With mild hypothermia, the SpO2 decreased (P<0.05) and there was no difference in SaO2 between control group and mild hypothermia group (P>0.05). After 24 hours of hypothermic treatment, The PO2 and pH value increased and the PCO2 decreased gradually, and they returned to the normal levels. There was no difference in serum levels of K+, Na+ between control group and mild hypothermia group before cooling and after rewarming (P>0.05). Serum levels of K+ in mild hypothermia group were significantly lower than those in control group at 24, 48, 72 hours after cooling. There was no different in Na+ levels between two groups in every period. The mortality of control group higher than mild hypothermia group (P<0.05).Conclusions: Mild hypothermia can decrease ICP. Mild hypothermia can alleviate the metabolic disorder of the brain tissue and improve the prognosis in the early stage of brain injury. The dynamic monitoring technique used for the oxygen saturation, blood gas analysis and electrolyte measurement have important significance for judging injury condition and instructing treatment in clinic.
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