A Study Of Change Of Brain Tissue Partial Pressure Of Oxygen In The Course Of Mild Hypothermia Treatment Of Severe Traumatic Brain Injury

Object:To investigate dinical significant and changes of brain tissue partial pressure of oxygen(PtiO₂)in the course of mild hypothermia treatment(MHT)of severe traumatic brain injury(sTBI).Methods:There were 38 cases in the course of mild hypothermia treatment of severe traumatic brain injury(sTBI).Intracranial pressure(ICP),jugularn venous oxygen saturation(SjvO₂),PtiO2,cerebral perfusion pressure,(CPP),lactate-oxygen index (LOI)and saturation of arterial blood oxygen(SaO₂)were continuously monitored in 38 cases with sTBI for analyzing the correlations insides.Clinical outcomes were valued using the Glasgow Outcome Scale score(GOSs).Results:(1)Increasing PtiO₂,SjvO₂,CPP and ICP,lactates were found dereased obviously after the course of MHT for 38 cases with sTBI..(2)There was negative linear correlation between PtiO₂ and ICP.(3)There was positive linear correlation between PtiO₂ and SjvO₂.(4)The specifity to predicted ischemia is 7.1.4%wih PtiO₂ values.It is higher than LOI,54.5%。The sensitivity to predicted ischemia is 96.4% wih LOI values,but specifity is 54.5%.(5)Increasing PtiO₂ and CPP were found obviously from the begain of MHT for 38 cases with sTBI.But there were no changes between PtiO₂ and CPP after 36h and of MHT.Conclusion:Continuous monitoring of PtiO₂ can reflect the condition of regional cerebral oxygen metabolism and guide treatment and predicting outcome.Decreasing PtiO₂ can be found after MHT.