Therapy Of PCOS With Combination Of Daine35 And Metformin And The Result Of Clomiphene Citrate On Ovulation Induction

Objective To investigate the effects of daine35 combine with metformin in patients with polycystic ovary syndrome(PCOS) and the relationship between the effects and the result of ovulation induction by clomiphene citrate(cc). Methods A total of 18 patients (65 cycles) with PCOS in our hospital selected were separated into two groups, Group 1 is whose BMI is less than 25 as Group 2 is whose BMI is no less than 25, are both treated with daine35 besides metformin from 2 to 7 cycles, test the serum hormones (FSH,LH,T,E,P,PRL), lipids(TC,TG,LDL-C), FINS and FPG and BMI, find the differences before and after the treatment. If the patients are amenorrhea, test the items the day when the patients in our center. Then, investigate the relationship between the effects and the results of ovulation induction with CC. The clinical diagnosis of PCOS was defined according to the consensus criteria for PCOS with the presence of clinical and biochemical signs of②hyperandrogenism,①chronic anovulation and/or oligomenorrhoea and③polycystic ovaries (The RotterdamESHRE/ASRM-sponsored PCOS consensus workshop group, 2004). And must foreclose other reasons which cause hyperandrogenism(adreno-genital syndrome,Cushing's syndrome,tumor secreting androgen) and some reasons which cause anovulation, as hyperprolacrinemia,premature ovarian failure,pituitary/ hypothalamic amenorrhea and abnormal thyroid function . Other criterias:④(LH≥10mmol/L and(or)LH/FSH≥2);⑤(TC≥1.80mmol/L and(or)TG≥6.0mmol/L and(or)LDL-C≥3.10mmol/L);⑥(HOMA-IR=FPG(mmol/L)×FINS(mU/L)/22.5≥3.8[3]). Results After 2-7 cycles, all patients have their regular menstrual cycles,①get right. After treatment, BMI,FSH,LDL-C,TC,TG in group 1 decline, LH,LH/FSH,T decline observably (P<0.05).①,②,⑤improve from 2 cycles, when③,④from 3-4cycles. Only two patients in group 1 have⑥. The only one patient with amenorrhea, after treated 7 cycles, criteria③,⑤,⑥don't improve;In group 2,after treatment, BMI,LH,LH/FSH,T,TC,TG decline observably (P<0.05), BMI<25, IR improve(P<0.05).②improve from 2 cycles, when①④⑤from 3-4cycles,③⑥from5-6cycles. Four patients have⑥. The only one patient with amenorrhea, who treats 7 cycles, criteria③,⑤,⑥don't improve. After the treatment, all patients in the two groups become better. BMI,TC,TG,IR in group 2 decline more observably to group 1(p<0.05), and①,③,⑤use more cycles to get better. There are more⑥in group 1 than group 2, which get better from 3-4 cycles. After using daine35 besides metformin 3-6 cycles, six patients in twelve ovulate: three with no criteria abnormal,one with BMI≥25,one with polycystic ovaries,one with④;three with no criteria abnormal,one with BMI≥25 who lose her weight from 130kg to 100kg. The patients with amenorrhea get bad results of ovulation. Conclusions The effects of daine35 combine with metformin in patients with polycystic ovary syndrome is fine. Improve①,③,⑤in the patient with BMI≥25 use more treatment cycles than those whose BMI<25. After using daine35 besides metformin 3-6 cycles, the the results of ovulation induction with CC is better. Before the ovulation induction with CC, the patients with no criteria abnormal and BMI≥25 who lose her weight successfully get better results. Two patients with one of the items abnormal, get ovulation but no pregnancy. The patients with amenorrhea get bad results of ovulation.