Font Size: a A A

Evaluation Of In Patients With Coronary Artery Disease Before And After Left Ventricular Regional Function By Strain Rate Imaging

Posted on:2010-08-22Degree:MasterType:Thesis
Country:ChinaCandidate:L N SuFull Text:PDF
GTID:2144360272496471Subject:Clinical Medicine
Abstract/Summary:PDF Full Text Request
Coronary atherosclerotic heart disease is a common disease which seriously harms human health and the incidence of coronary heart disease in our country have increased year-on-year. Percutaneous coronary intervention (PCI) is a means of effective treatment of coronary heart disease. The analysis for heart wall motion is not only an important aspect of the diagnosis of coronary heart disease, but also an important guiding significance of the observation and prognosis of the therapeutic effect of coronary heart disease. Echocardiography as a non-invasive, repeatable operation, cheaper way to check, has been in the diagnosis of coronary heart disease played an important role. Observation of wall motion was considered as the more sensitive indicator of diagnosing the myocardial ischemia which occurred earlier than ECG ST segment-T wave changed.Strain rate imaging (SRI) is a new technology derived from tissue Doppler in recent years.Strain is a physical term, refers to solid objects from a certain direction based on state changes to the amount of strain rate (SR) is the strain per unit time. Strain, and strain rate is the nature of the research objects, reflect the characteristics of myocardial tissue itself, as the strain rate reflects the velocity gradient between two points of the spatial distribution and rule out the possibility of myocardial effects of the traction by the surrounding tissue.This study used strain rate imaging techniques, observation of 50 cases of normal group and 43 cases of the experimental group (patients with coronary heart disease) in before PCI treatment and 1 week and 1 month after PCI treatment on detection of a segmental left ventricular myocardial strain rate peak contraction period SRs, diastolic and late diastolic SRe early SRa). The results showed that normal myocardial strain rate from the basal segment gradually reduced to the apical segment, basal segment with the largest, but the difference was not statistically significant. Patients with normal preoperative corresponding segments compared with ischemic patients preoperative segment SRs, SRe significantly lower, the difference was significant (P <0.05), SRa no significant changes. Negative normal PSS, the basal segment, the middle segment to the apex of a gradual increase in strain above, pre-operative patients without corresponding changes in the law, part of the apical segment in patients with PSS for the reverse wave, SRs significantly lower waveform disorders, and normal group difference between the corresponding segments are significant (P <0.05). Preoperative patients ischemic segments SRs, SRe, PSS decreased significantly, SRa no significant changes. All 43 cases of patients underwent PCI for the treatment, treatment after 1 week and 1 month segment ischemia SRs, SRe, PSS, compared with preoperative increased significantly (P <0.05), after 1 month segment when the majority of SRs, SRe, PSS than after 1 week was significantly increased, the difference was significant (P <0.05), before and after treatment was no significant difference Sra value (P <0.05); after a section on the majority of paragraph SRs, SRe, PSS values measured with the normal group, the difference was not significant (P <0.05). But there is still a small number of segments SRs, SRe, PSS is still lower than the normal group (P <0.05). Therefore, the functional recovery of ischemic myocardium is a process, but some may exist as a result of myocardial irreversible damage can not be fully restored, but it is undeniable that the vast majority of ischemic myocardial segments in myocardial function after PCI to be significantly improvement in the application of SRI to more accurately evaluate the function of PCI after recovery.The recovery of myocardial function after PCI to evaluate the effectiveness of revascularization is an important indicator. In this study, two-dimensional multi-plane measurement and MM-Teich measurements have shown that changes in left ventricular EF: after 1 week more than the preoperative increase (P <0.05); after 1 month and 40% of preoperative patients significantly increased to more than 50%, the difference was statistically significant (P <0.05). EF in two-dimensional multi-plane measurements were lower than MM-Teich (including before and after treatment) (P <0.05). The results show that the acceptance of PCI can be significantly improved after treatment of left ventricular function. At present, common clinical MM-Teich determination of cardiac function, there are many factors interfered which subject to the accuracy of the impact but multi-plane method and two-dimensional depiction of the left ventricular volume using the three cross-section average of three measurements, more precise measurement of changes in EF.From this we concluded that the application of SRI technology can detect changes in myocardial ischemia, assessment of wall accurately distinguish between the activities of cardiac activity inconsistency, is a feasible method which can diagnose the existence of myocardial ischemia more earlier.The application of SRI technology evaluates PCI ischemic myocardial function improvement accurately, and prompts treatment of timely PCI can raise a good myocardial function in patients with coronary heart disease and for the understanding of regional myocardial function after PCI, provides an objective basis to improve in varying degrees. Application of two-dimensional multi-planar scanning method of left ventricular volume in the mining.Three measurements with the mean, than currently used clinical MM-Teich law can be a more accurate measurement of changes in EF.SRI imaging technology with its feature that includreal-time,quantitative evaluation of ventricular and wall motion and the regional characteristics of cardiac function is more concerned by clinical doctors gradually and become to the research focus in many of research institutions.In the strain-rate imaging, quantitative indicators to measure can identify patients with coronary artery disease and normal myocardium and ischemic myocardium well and the biological characteristics of strain rate determines its objectivity of segments to reflect wall motion , which provides more and better indicators of quantitative evaluation of wall motion for clinical;SRI technology is a kind of effective method for non-invasive quantitative evaluation of myocardia after PCI treatment and can evaluate the regional left ventricular function quantitatively and also provides a new a new non-invasive quantitative indicator for the effect of interventional treatment of heart disease and prognosis. With application of SRI in three-dimensional real-time, it will be further enriched and improved by echocardiography in the diagnosis of heart disease.With further study, as well as imaging technology continues to improve and develop,strain and strain rate imaging will be widely used in clinical diagnosis of cardiovascular disease.
Keywords/Search Tags:strain rate, coronary heart disease, left ventricular regional function
PDF Full Text Request
Related items