Effect Of Flurbiprofen Axetil On Levels Of Interleukin-2 And Interleukin-8 And Postoperative Analgesia In Patients With Rectal Surgery

Surgery is one of the most effective ways to treat tumors. However, not only does the surgery heal diseases, but also bring inevitable effects to patients. The stress factors including infection, pain, trauma and feeling have harmful effects on both patients'physical rehabilitation and qualities of life. Pain has become the fifth member of vital signs, which contains blood pressure, pulse, respiratory and temperature. More and more anesthetists pay attention to the problem that how to effectively reduce the adverse effects of perioperative pain.The definition of preemptive analgesia is that a measure priors to the beginning of pain, so that it can prevent the transmission of painful signals. It can enhance analgesic effects and decrease the occurrence of postoperative complications. Many scholars have proved that flurbiprofen axetil plays a role in analgesia. Flubiprofen axetil is one of non-steroidal anti-inflammatory analgesic drugs, taken lipid microspheres as targeting vector for the analgesic effect. It inhibits the production of prostagland by inhibiting the activity of cycloxygenase. It has been widely used in the treatment of pain, but the researchs about the effect of flurbiprofen axetil on serum levels of interleukin-2 and interlenkin-8 and postoperative analgesia in patients with rectal surgery can't be founded.Objective: To observe the effect of flurbiprofen axetil on serum levels of interleukin-2 and interleukin-8 and postoperative analgesia used in patients with rectal surgery.Methods: Twenty patients undergoing rectal surgery, ASAⅠ-Ⅱ, 55-75 years old, randomized to two groups with 10 cases each: group F and group N. The patients of group F were injected intravenously flurbiprofen axetil 1mg/kg at the end of anesthesia induction and the completion of operation, while the patients of group N were injected normal saline. The patients were adopted total intravenous anesthesia received patient controlled intravenous analgesia (PCIA) with sulfentanyl after surgery. Sulfentanyl 150μg plus granisetron 6mg to 150ml normal saline were fixed the PCIA pump. The parameters contained that loading dose 5ml, bolus 2ml, lockout time 15min, background dose 2ml/h, maximal dose 15ml/h. The analgesic effect was reflected by visual analog scale (VAS) at 2, 4, 8, 12, 24h after operation. The consumed dosage of sulfentanyl and effective numbers of PCIA pump in postoperative 24 hours were recorded. The venous blood was collected at the time of 10 minutes before induction of anesthesia, 3, 8, 24 hour after operation. Then, we will determine the serum levels of interlenkin-2 and interleukin-8.Results: There were no significant differences in patients'age, weight and operation time between the two groups (P>0.05). Moreover, the VAS of postoperative 2,4,8,12,24 hour didn't have statistical significance (P>0.05). The total consumed dosage of sulfentanyl in 24 hours and the effective frequencies of PCA in group F were significantly less than that in group N (P<0.05). The concentration of interleukin-2 of two groups at T1, T2, T3 was lower than it at T0 (P<0.05). The serum level of interlenkin-2 of group N was significantly lower than group F at T1, T2, T3 (P<0.05), there were statistical significances between two groups. Concerned the level of interleukin-8 at T0, there were no significant differences between two groups (P>0.05). However, the concentration of interlenkin-8 of group N was significantly higher than group F at T1, T2,T3 (P<0.05).Conclusion: Preemptive administration of flurbiprofen axetil might obviously reduce the dosage of sulfentanyl in 24 hours and obtain the definite analgesic effects after rectal surgery. Flurbiprofen axetil could be regulate the inflammatory response through the inhibition of the postoperative expression of interleukin-8. It also can enhance the immunoprotection by inhibiting the postoperative concentration of interleukin-2 become lower. In brief, preemptive administration of flurbiprofen should be conductive to the patients'physical rehabilitation.