The Potency And Safety Of Triptolide In Antifertility Action

Objective To perform further approach on the site of action and safety of triptolide alcohol in antifertility action.Methods:Healthy male Wistar rats were selected to observe the impact of triptolide alcohol on the gonepoiesis and testicle, epididymis and the internal organs, eg.heart, liver and kidney and etc., the experiment was categorized into two phases, in the first phase, the rats of the experimental group were fed with triptolide alcohol 0.05mg/kg·d,6d per week,and continued for 8w, 1% dimethyl sulfoxide DMSO-made,1% dimethyl sulfoxide DMSO was fed in the control group,2ml/kg·d,in the second phase,the rats of the experimental group were fed with triptolide alcohol0.1mg/kg·d,0.05mg/kg·d,0.03mg/kg·d,6d per week,and continued for 4w,the rats of the control group were fed with 1%DMSO,and weighed every week, and draw the materials to observe the state of testicle androgone apoptosis, epididymis azzospermia and the impacts on the heart, liver, kidney and testicle.Results :Azzospermia in experimental group was significantly declined, rat azzospermia (dosage≥0.05mg/kg·d) was 0,in vivo testicle contorted seminiferous tubules seminiferous epithelium was damaged, invivo lumens epithelium had some abation, no morphological anomaly was observed in the rats of control group. testicle androgone apoptosis was detected by flow cytometer, no marked difference was present between experimental group and control group,no significant deviation was found in triptolide alcohol with different dosage in the murine weights of experimental group and control group.Conclusion:Triptolide was shown to be an effective drug in antifertility and with trivial tissue toxicity,and its contraceptive effect is secure.