The Expression And Significance Of ILK And PI3-k In The Placenta Of Preeclampsia

Objective:To study the expression of ILK and PI3-K in placenta of normal pregnancy and preeclampsia,and then understand the mechanism of ILK and PI3-K in preeclampsia.Methods:Get the placenta after 37 weeks gestation from October.2006 to March.2007 in the Union Hospital .The samples were divided into 15 cases in mild preeclampsia group ,10 cases in severe preeclampsia group and 15 cases in the normal pregnant women(control group).Use the immunohistochemistry to determine the intensity of ILK and PI3-K staining in placenta of normal pregnancy and preeclampsia and examine the corresponding ILK-mRNA by RT-PCR.Results:ILK and PI3-K proteins were observed in trophoblast in the placentas.Expression of ILK and PI3-K decreased dramatically in the placentas of severe superimposed pre-eclampsia (P<0.01).Conclusion:ILK and PI3-K may be involved in the pathologies of preeclampsia...