Expression Of HIPK2 And Its Correlation With Apoptosis In Cervical Intraepithelial Neoplasia

Objective: Homeodomain-interacting protein kinase 2 (HIPK2) is a member of a recently identified nuclear protein kinase family that act as corepressors for homeodomain transcription factors. This study was carried out to investigate the expression of HIPK2 in CINâ… , CINâ…¡and CINâ…¢, and its correlation with apoptosisMethods: 65 cases of CIN and 10 cases of normal cervical tissue were analyzed retrospectively. The expression of HIPK2, p53, proliferating cell nuclear antigen (PCNA) and apoptosis were detected by immunohistochemistry and tunnel retrospectively. The correlation of HIPK2 and p53, PCNA, as well as apoptosis was statistically analyzed.Results: The expression of HIPK2 was significantly lower in CINâ… than in CINâ…¡/â…¢(P<0.05), also its expression in normal cervical tissue was lower than CINâ… (P<0.05), indicating that HIPK2 expression is correlated with the development of cervical cancer, The expression of PCNA was also significantly lower in CIN I than in CINâ…¡/â…¢(P<0.05), but the different expression of p53 in CINâ… and CINâ…¡/â…¢was not statistically significant ,and there was no correlation between HIPK2 and p53, but there was significant correlation between HIPK2 and apoptosis.Conclusion: The expression of HIPK2 may play an important role in cervical carcinogenesis and may correlate with apoptosis while not with p53 in cervical cancer.