Therapeutic Effects Of Compound Glycyrrhizin Liposome On Rats With Nonalcoholic Steatohepatitis

Objective:To investigate the therapeutic effects of compound glycyrrhizin liposome on the rats with nonalcoholic steatohepatitisMethods:35 male SD rats were randomly divided into 4 groups:the model group(n=10),compound glycyrrhizin control group(n=10)and compound glycyrrhizin liposome treated group(n=10) ,the 30 rats all were fed with fat-rich diet,and the normal group(n=5) with normal diet.Drug was given to each group after 8 weeks:the model group were given normal saline (2.0ml/kg) ; the control group were given compound glycyrrhizin injection(2.0ml/kg);the treated group were given compound glycyrrhizin liposome injection(2.0ml/kg) , the three groups all were given by intraperitoneal injection every other day.No any drug was given in normal group.All rats were sacrificed at week 16.The serum levels of ALT,AST and GGT were measured with auto-biochemistry instrument.The hepatic histologic scores on fat-liver and inflammation of NASH were done according to the guidelines of the diagnosis and treatment of NAFLD in February 2006.Results:The weight and liver index of the three rich-fat diet groups were higher than the normal group,but similar among the three rich-fat diet groups. Compared with model group, the blood-serum levels of AST and GGT both reduced significantly in treated group(P<0.05及P<0.01), the hepatic histologic scores on inflammation of NASH reduced remarkably in treated group(P<0.01);Compared with control group , the hepatic histologic scores on inflammation of NASH and the blood-serum levels of GGT both reduced remarkably in treated group(P<0.01).Conclusion:Compound glycyrrhizin liposome is effective in treatment of rats with steatohepatitis induced by fat-rich diet .