Prevalence And Risk Factors Study Of Chronic Kidney Disease In Chronic Hepatitis B Or C Infections Patient

Objective To investigate the prevalence of chronic kidney disease(CKD) and risk factors in the chronic hepatitis B or C infections patient.Participants 1001 chronic hepatitis B or C infections patient(older than 18 years) from 2002～2007 years Hospitalization therapeutic of Beijing Universities people hospitals.Methods All patient Recorded morning spot urine dipstick of proteinuria(abnormal:≥0.25 g/L) and hematuria confirmed by urine microscopy (abnormal:>3 red blood cells /HP);and MDRD equation estimated GFR[abnormal: <60ml·min^-1·(1.73m²)^-1].The associations of kidney damage indicators with age,gender,diabetes,hypertension,hepatitis B virus deoxyribonucleic acid,hepatitis C virus ribonucleic acid,alanine aminotransferase and blood uric acid were examined.The 13.0 SPSS statistics software package was used for statistical analysis,Data were expressed as mean±SE;the group comparison by t-test;the enumeration data by X² test;the data were analyzed by Logistic regression to explore the independent and correlated risk factors for chronic kidney disease.Results eligible data of 765 chronic hepatitis B infections subjects were enrolled in the study.the prevalence of proteinuria was20%;hematuria 11.1%; and reduced eGFR 6.4%.Approximately 28.5%subjects had at least one indicator of kidney danage.After the adjustment of age and gender component,the prevalence of proteinuria was 19.61%(95%CI:13.02%～26.2%);hematuria9.13%(95%CI:6.72%～11.54%);and reduced eGFR 3.54%(95%CI:2.05%～5.03%).Approximately 26.41% (95%CI:18.26%～24.56%) subjects had at least one indicator of kidney danage. Age,glutamate and blood uric acid were independently associated with CKD. eligible data of 235 chronic hepatitis C infections subjects were enrolled in the study.the prevalence of proteinuria was12.8%;hematuria 6.0%;and reduced eGFR 12.8%.Approximately 24.7%subjects had at least one indicator of kidney danage. Age and blood uric acid were independently associated with CKD.Conclusions After the adjustment of age and gender component,The prevalence of chronic kidney disease is 26.41%in chronic hepatitis B infections patient:The prevalence of chronic kidney disease is 24.7%in chronic hepatitis C infections patient.Independent risk factors associated with kidney damage discern are Age,glutamate and blood uric acid:Age and blood uric acid.