| Objective: To investigate the correlative factors resulting in missed abortion and the rising of pregnant woman's Bpb(blood pb),analyze the relationship between Bpb and missed abortion,seek the tendency between air pb pollution and missed abortion by using air pb data of Tianjin.Methods: This study is divided into two parts: case-control study based on hospital and case-control study based on community. At first, a comparative analysis on 94 abnormal pregnant cases and 94 normal counterparts in Tianjin Armed Police Hospital and DongLi Women and Children Health-care Hospital from December 2006 to November 2007 is carried out by using paired study method. A questionnaire is done and 3 ml blood of each pregnant woman in all the cases is collected for Bpb detection by means of Graphite stove atomic absorption spectrophotomete.Seeked the effective factors of rising Bpb and missed abortion by statistic analysizing.Secondly, the effect of air pb pollution on pregnant outcome is analyzed based on the 2658cases of normal pregnancy and missed abortion respectively in early pregnancy in 15 community hospitals from 2001 to 2006 and air pb pollution data obtained from six air pollution monitor stations in Tianjin at the same time. All the Data are analyzed by SPSS 10.0 software.Results: Firstly,The relationship between Bpb level and missed abortion.the case-control study based on hospital shows that missed abortion in early pregnancy is correlated with the level of Bbp, and the Bbp level of normal pregnancy and missed abortion is 59.51±13.63μg/L,87.17±28.98μg/L respectively,P<0.05. The Bbp level of recurrent missed abortion is 87.17±21.38μg/L which is obviously higher than the normal group, and is similar to abnormal pregnancy group (no statistic significance), which shows that high Bbp level maybe one con-effect etiology factor. The effective factors concerning pregnant women's high Bpb level are career, education, poison contacting during pregnancy, family fuel, time spending on traffic everyday, the distance from house toroad, supplement of Ca and Vit pregnancy or preceding and ETS ( Exposure to environmental tobacco smoke in pregnancy).Bring all these factors into liner regression equation. We find zhe main effective factors are supplement of Vit pregnancy,the distance from house toroad, supplement of Vit Ca pregnancy the value of B is -18.445,-16.303,-9.700.Secondly, the effective factors resulting in missed abortion. The effective factors resulting in abnormal pregnancy are career, husbands'career,education, poison contacting during pregnancy and poison contacting of the husband, family fuel, time spending on traffic everyday,recent indoor decoration, distanc from house to road, supplement of Ca and Vit pregn- ancy or preceding and ETS. Bring all these factors into Logistic regression equation. It is found that factors affecting pregnancy outcome in terms of seriousness are as follows: recent indoor decoration , vocational exposure of pregnant woman , supplement of Vit pregnancy, husband's poison contacting, distance from home toroad, and the effect index B are 1.589,1.411,-1.391,1.271,-1.098,respectively,and the risk factors are recent indoor decoration, husband's poison contacting , vocational exposure of pregnant woman,the proect factor are supplement of Vit pregnancy, distance from home to road.Thirdly, relationship between air pb level and missed abortion.It is showed that from 2001 to 2006 lead particles in air in downtown Tianjin rising firstly and falling lately in the retrospective cohort study: X2=12.463,P=0.02<0.05. Compared variables each other ,the level of pb in the year of 2001,2002, 2005,2006 is obviously lower than that in the year of 2003 and 2004. Accordingly, the constitutive rate of missed abortion in early pregnancy in 2005 is obviously lower than that in 2003 The rate of missed abortion is 42.3%,55.9%,(X2 =47.183 ,P<0.01). It is also observed that the level of air pb in July is obviously lower than that in January based on the air data in Tianjin, t=2.342, P<0.05. The level of air pb is 0.345±0.182μg/M3,0.553±0.488μg/M3 respectively. The rate of missed abortion shows a parallel tendency that the highest point appears in December and March, the lowest point lies in September. The rate is 64.9%,61.3%, and 34.1% respectively(X2=29.412, P<0.01). Compared variables each other, the rate in May, July, Aμgust, September, February, October are lower than that in January, March, April, June, November, and December. And the rate of missed abortion and air pb level in winter and spring are obviously higher than that in summer and autumn yearly.Conclusion: Pregnant women's high level Bpb is correlated with missed abortion. The protected factors of rising Pregnant women's Bpb and missed abortion are supplement of Vit pregnancy and distance from home to road exceed 60M, and we find that the precent of missed abortion is correlated with air pb level. |
