Meta-analysis Of Adjuvant Progesterone Therapy In Stage Ⅰ And Ⅱ Endometrial Carcinoma

Objective:This study was to evalute the effect of adjuvant progesterone therapy on stage I and stage II endometrial carcinoma after radical surgery.Methods:Randomized controlled trials on surgery plus progesterone therapy and surgery alone for patients with stage I and stage II endometrial carcinoma. Documents ended in Dec. 2007 were selected from PubMed,Science Direct, Proquest,Springer,OVID,CNKI,CBMdisc databases.Results:Five reports were included in the Meta-analysis and a total of 3132 patients had been included. Compared with the patients underwent surgery alone , both result of death risks and relapse risks of surgery plus progesterone therapy were similar: the combined OR of all death risks is 1.01( P=0.92, 95% confidence interval =0.85~1.20);the combined OR of relapse risks is 0.88( P=0.34, 95% confidence interval =0.67~1.15).Conclusion:Adjuvant progesterone therapy cannot reduce the prognosis of stage I and II endometrial carcinoma.